Laboratoire de Bactériologie (Bacteriological Laboratory)

2. Where is it located (include both address and geographical location)?

Laboratoire de Bactériologie, Hôpitaux Universitaires de Genève, Rue Gabrielle Perret-Gentil 4, CH-1205 Genève 14, Switzerland

N 46° 11' 37.20", E 6° 8' 59.92"

3. Floor area of laboratory areas by containment level
BL 3 , 74.00 SqM
BL 2 , 394.00 SqM
Total laboratory floor area (SqM)

4. The organizational structure of each facility

(viii) Briefly describe the publication policy of the facility

Publication in peer-reviewed open literature.

(ix) Provide a list of publicly-available papers and reports resulting from the work published during the previous 12 months. (To include authors, titles and full references)

Outbreak of Pseudomonas aeruginosa producing VIM carbapenemase in an intensive care unit and its termination by implementation of waterless patient care.
Catho G,Martischang R,Boroli F,Chraïti MN,Martin Y,Koyluk Tomsuk Z,Renzi G,Schrenzel J,Pugin J,Nordmann P,Blanc DS,Harbarth S
Crit Care. 2021 Aug 19;25(1):301. doi: 10.1186/s13054-021-03726-y.
[Abstract] [PubMed]

Performance of Fully Automated Antimicrobial Disk Diffusion Susceptibility Testing Using Copan WASP Colibri Coupled to the Radian In-Line Carousel and Expert System.
Cherkaoui A,Renzi G,Vuilleumier N,Schrenzel J
J Clin Microbiol. 2021 Aug 18;59(9):e0077721. doi: 10.1128/JCM.00777-21. Epub 2021 Aug 18.
[Abstract] [PubMed]

The human gut mycobiome and the specific role of Candida albicans: where do we stand, as clinicians?
Musumeci S,Coen M,Leidi A,Schrenzel J
Clin Microbiol Infect. 2021 Aug 4:S1198-743X(21)00429-8. doi: 10.1016/j.cmi.2021.07.034.
[Abstract] [PubMed]

The Potential Role of Clinical Metagenomics in Infectious Diseases: Therapeutic Perspectives.
d'Humières C,Salmona M,Dellière S,Leo S,Rodriguez C,Angebault C,Alanio A,Fourati S,Lazarevic V,Woerther PL,Schrenzel J,Ruppé E
Drugs. 2021 Jul 30:1-14. doi: 10.1007/s40265-021-01572-4.
[Abstract] [PubMed]

Populations of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae are different in human-polluted environment and food items: A multicentre European study.
Martak D,Guther J,Verschuuren TD,Valot B,Conzelmann N,Bunk S,Riccio ME,Salamanca E,Meunier A,Henriot CP,Brossier CP,Bertrand X,Cooper BS,Harbarth S,Tacconelli E,Fluit AC,Rodriguez-Baño J,Kluytmans JAJW,Peter S,Hocquet D
Clin Microbiol Infect. 2021 Jul 26:S1198-743X(21)00414-6. doi: 10.1016/j.cmi.2021.07.022.
[Abstract] [PubMed]

New insights into pneumonia in patients on prolonged mechanical ventilation: need for a new paradigm addressing dysbiosis.
Rello J,Schrenzel J,Tejo AM
J Bras Pneumol. 2021 Jun 23;47(3):e20210198. doi: 10.36416/1806-3756/e20210198.
[Abstract] [PubMed]

12/111phiA Prophage Domestication Is Associated with Autoaggregation and Increased Ability to Produce Biofilm in Streptococcus agalactiae.
Renard A,Diene SM,Courtier-Martinez L,Gaillard JB,Gbaguidi-Haore H,Mereghetti L,Quentin R,Francois P,Van Der Mee-Marquet N
Microorganisms. 2021 May 21;9(6):1112. doi: 10.3390/microorganisms9061112.
[Abstract] [PubMed]

Performances of automated digital imaging of Gram-stained slides with on-screen reading against manual microscopy.
Fischer A,Azam N,Rasga L,Barras V,Tangomo M,Renzi G,Vuilleumier N,Schrenzel J,Cherkaoui A
Eur J Clin Microbiol Infect Dis. 2021 May 8. doi: 10.1007/s10096-021-04233-2.
[Abstract] [PubMed]

Distribution of pathogens and antimicrobial resistance in bacteraemia according to hospitalization duration: a nationwide surveillance study in Switzerland.
Buetti N,Marschall J,Timsit JF,Atkinson A,Kronenberg A,Sommerstein R
Clin Microbiol Infect. 2021 Apr 30:S1198-743X(21)00212-3. doi: 10.1016/j.cmi.2021.04.025.
[Abstract] [PubMed]

Temporal and regional incidence of carbapenemase-producing Enterobacterales, Switzerland, 2013 to 2018.
Ramette A,Gasser M,Nordmann P,Zbinden R,Schrenzel J,Perisa D,Kronenberg A
Euro Surveill. 2021 Apr;26(15):1900760. doi: 10.2807/1560-7917.ES.2021.26.15.1900760.
[Abstract] [PubMed]

Household acquisition and transmission of extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae after hospital discharge of ESBL-positive index patients.
Riccio ME,Verschuuren T,Conzelmann N,Martak D,Meunier A,Salamanca E,Delgado M,Guther J,Peter S,Paganini J,Martischang R,Sauser J,de Kraker MEA,Cherkaoui A,Fluit AC,Cooper BS,Hocquet D,Kluytmans JAJW,Tacconelli E,Rodriguez-Baño J,Harbarth S
Clin Microbiol Infect. 2021 Jan 7:S1198-743X(20)30784-9. doi: 10.1016/j.cmi.2020.12.024.
[Abstract] [PubMed]

Case Report: About a Case of Hyperammonemia Syndrome Following Lung Transplantation: Could Metagenomic Next-Generation Sequencing Improve the Clinical Management?
Michel C,Raimo M,Lazarevic V,Gaïa N,Leduc N,Knoop C,Hallin M,Vandenberg O,Schrenzel J,Grimaldi D,Hites M
Front Med (Lausanne). 2021 Jul 6;8:684040. doi: 10.3389/fmed.2021.684040. eCollection 2021.
[Abstract] [PubMed]

Unexpectedly High False-Positive Rates for Haemophilus influenzae Using a Meningoencephalitis Syndromic PCR Panel in Two Tertiary Centers.
Zanella MC,Cherkaoui A,Hinic V,Renzi G,Goldenberger D,Egli A,Schrenzel J
Front Cell Infect Microbiol. 2021 Mar 8;11:639658. doi: 10.3389/fcimb.2021.639658. eCollection 2021.
[Abstract] [PubMed]

Oral Dysbiosis and Inflammation in Parkinson's Disease.
Fleury V,Zekeridou A,Lazarevic V,Gaïa N,Giannopoulou C,Genton L,Cancela J,Girard M,Goldstein R,Bally JF,Mombelli A,Schrenzel J,Burkhard PR
J Parkinsons Dis. 2021;11(2):619-631. doi: 10.3233/JPD-202459.
[Abstract] [PubMed]

5. Briefly describe the biological defence work carried out at the facility, including type(s) of micro-organisms(9) and/or toxins studied, as well as outdoor studies of biological aerosols.

The Bacteriological Laboratory, which is part of the University Hospitals of Geneva, is the Regional Competence Center for the primary analysis of bacteriological samples suspicious of a bioterror-related background. Protocols for the detection of bacteria causing anthrax, plague, tularemia and brucellosis have been established in close collaboration with the National Reference Center for Anthrax. Furthermore, there is a strong link between the Bacteriological Laboratory and the Genomic Research Laboratory that is almost exclusively executing basic and applied research projects under joint leadership. Translational research is actively promoted through this channel of cooperation.

For further information please visit (website in French):

(9) Including viruses and prions.