Labor Spiez (Spiez Laboratory)

2. Ubicación (dirección y lugar geográfico)
Labor Spiez, Bundesamt für Bevölkerungsschutz, Eidgenössisches Departement für Verteidigung, Bevölkerungsschutz und Sport, Austrasse, CH-3700 Spiez, Switzerland

N 46° 41' 26.32", E 7° 38' 39.41"

3. Superficie de los laboratorios por nivel de contención
BL 4 , 118.00 m2
Of note, the BSL4 unit is operational and holds a license as follows: “Development of methods to detect and analyze viral pathogens of risk group 4 (clinical samples, environmental samples, including samples suspect of bioterrorism origin) as well as evaluation of antiviral substances, neutralizing antibodies and decontamination solutions”.
BL 3 , 126.00 m2
BL 2 , 483.00 m2
Superficie total de laboratorios (m(2))

4. Estructura orgánica de cada instalación

(viii) Describa brevemente la política de publicaciones de la instalación

Publication in open literature.

(ix) Enumere los trabajos e informes que se han hecho públicos resultantes de la labor desarrollada y publicados en los últimos doce meses (con indicación de autores, títulos y referencias completas)

Tularemia in Children and Adolescents. 
Imbimbo C, Karrer U, Wittwer M, Buettcher M.
Pediatr Infect Dis J. 2020 Dec;39(12):e435-e438. doi: 10.1097/INF.0000000000002932.
PMID: 33003104 No abstract available. 

Author Correction: In vitro virucidal activity of Echinaforce®, an Echinacea purpurea preparation, against coronaviruses, including common cold coronavirus 229E and SARS-CoV-2. 
Signer J, Jonsdottir HR, Albrich WC, Strasser M, Züst R, Ryter S, Ackermann-Gäumann R, Lenz N, Siegrist D, Suter A, Schoop R, Engler OB.
Virol J. 2020 Nov 9;17(1):172. doi: 10.1186/s12985-020-01439-2.
PMID: 33168000 Free PMC article. 

Accuracy of serological testing for SARS-CoV-2 antibodies: First results of a large mixed-method evaluation study. 
Brigger D, Horn MP, Pennington LF, Powell AE, Siegrist D, Weber B, Engler O, Piezzi V, Damonti L, Iseli P, Hauser C, Froehlich TK, Villiger PM, Bachmann MF, Leib SL, Bittel P, Fiedler M, Largiadèr CR, Marschall J, Stalder H, Kim PS, Jardetzky TS, Eggel A, Nagler M.
Allergy. 2020 Sep 30:10.1111/all.14608. doi: 10.1111/all.14608. Online ahead of print.
PMID: 32997812 Free PMC article. 

In vitro virucidal activity of Echinaforce®, an Echinacea purpurea preparation, against coronaviruses, including common cold coronavirus 229E and SARS-CoV-2. 
Signer J, Jonsdottir HR, Albrich WC, Strasser M, Züst R, Ryter S, Ackermann-Gäumann R, Lenz N, Siegrist D, Suter A, Schoop R, Engler OB.
Virol J. 2020 Sep 9;17(1):136. doi: 10.1186/s12985-020-01401-2.
PMID: 32907596 Free PMC article. 

Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration. 
Zysset-Burri DC, Keller I, Berger LE, Largiadèr CR, Wittwer M, Wolf S, Zinkernagel MS.
NPJ Genom Med. 2020 Sep 1;5:34. doi: 10.1038/s41525-020-00141-0. eCollection 2020.
PMID: 32922859 Free PMC article. 

Reduced maximal aerobic capacity after COVID-19 in young adult recruits, Switzerland, May 2020. 
Crameri GAG, Bielecki M, Züst R, Buehrer TW, Stanga Z, Deuel JW.
Euro Surveill. 2020 Sep;25(36):2001542. doi: 10.2807/1560-7917.ES.2020.25.36.2001542.
PMID: 32914744 Free PMC article. 

Social distancing alters the clinical course of COVID-19 in young adults: A comparative cohort study. 
Bielecki M, Züst R, Siegrist D, Meyerhofer D, Crameri GAG, Stanga ZG, Stettbacher A, Buehrer TW, Deuel JW.
Clin Infect Dis. 2020 Jun 29:ciaa889. doi: 10.1093/cid/ciaa889. Online ahead of print.
PMID: 32594121 Free PMC article. 

Evaluation of Viral RNA Recovery Methods in Vectors by Metagenomic Sequencing. 
Akello JO, Leib SL, Engler O, Beuret C.
Viruses. 2020 May 19;12(5):562. doi: 10.3390/v12050562.
PMID: 32438629 Free PMC article. 

T-cell immunoglobulin and mucin (TIM) contributes to the infection of human airway epithelial cells by pseudotype viruses containing Hantaan virus glycoproteins. 
Mayor J, Torriani G, Rothenberger S, Engler O.
Virology. 2020 Apr;543:54-62. doi: 10.1016/j.virol.2020.02.002. Epub 2020 Feb 9.
PMID: 32056847 

Antimicrobial resistance classification using MALDI-TOF-MS is not that easy: lessons from vancomycin-resistant Enterococcus faecium. 
Brackmann M, Leib SL, Tonolla M, Schürch N, Wittwer M.
Clin Microbiol Infect. 2020 Mar;26(3):391-393. doi: 10.1016/j.cmi.2019.10.027. Epub 2019 Nov 1.
PMID: 31682986 No abstract available. 

Archivos adjuntos
5. Describa brevemente la labor desarrollada por la instalación en materia de defensa biológica, con indicación de los tipos de microorganismos(9) y/o toxinas estudiados, así como las investigaciones al aire libre sobre los aerosoles biológicos

Spiez Laboratory, which is part of the Federal Office for Civil Protection, is the Swiss Center of Expertise in NBC Protection. Its Biology Division has a range of activities including research, development, test & evaluation, training, as well as diagnosis in the fields of virology, bacteriology, toxinology and biosafety. The tasks include analysis of unknown samples, diagnostics and identification of potential biological warfare and bioterror agents, food and water analysis for the Swiss Armed Forces, and research & development in coordination with contractors. Spiez Laboratory deals with many different biological agents and toxins known to be pathogenic for humans.

Spiez Laboratory is also a National Reference Center mandated by the Swiss Federal Office of Public Health and a National Reference Laboratory mandated by the Swiss Federal Food Safety and Veterinary Office as follows:

  • National Reference Center for Anthrax
    • Bacillus anthracis (anthrax)
    • Francisella tularensis (tularemia)
    • Yersinia pestis (plague)
    • Brucella spp. (brucellosis)
    • Burkholderia pseudomallei (melioidosis)
    • other bacterial pathogens according to requirements of the national coordination committee of the Regional Laboratory Network
  • National Reference Center for Tick-Transmitted Diseases
    • Tick-borne encephalitis virus (TBE)
    • Coxiella burnetii (Q fever)
    • Borrelia burgdorferi s.l. (Lyme disease)
    • Other rare / emerging tick-transmitted pathogens
  • National Reference Laboratory for Staphylococcus enterotoxins
    • Staphylococcus enterotoxin B
    • other Staphylococcus enterotoxins

In addition, Spiez Laboratory supports the National Reference Center for Emerging Viral Infections responsible for the detection of emerging and reemerging viruses of all biosafety levels, especially hemorrhagic fever viruses and variola virus.

Spiez Laboratory's Biology Division holds an accreditation by the Swiss Accreditation Service as "Testing laboratory for the detection of biological agents" (STS 0054) according to the international standard ISO/IEC 17025:2017.

For additional information please visit:

(9) Comprendidos virus y priones.