Laboratoire de Bactériologie (Bacteriological Laboratory)

2. Emplacement de l’installation (indiquer l’adresse et les coordonnées géographiques)
Laboratoire de Bactériologie, Hôpitaux Universitaires de Genève, Rue Gabrielle Perret-Gentil 4, CH-1211 Genève 14, Switzerland

N 46° 11' 37.20", E 6° 8' 59.92"

3. Superficie des secteurs de laboratoire, par niveau de confinement
BL 3 , 74.00 m2
BL 2 , 394.00 m2
Superficie totale des laboratoires (m(2))
468

4. Organigramme de chaque installation

(viii) Décrire brièvement la politique adoptée en matière de publication dans l’installation.

Publication in open literature.

(ix) Fournir une liste des documents et rapports accessibles au public qui portent sur les travaux publiés au cours des douze mois écoulés (indiquer les auteurs, les titres et les références complètes).

Molecular characterization of fluoroquinolones, macrolides, and imipenem resistance in Haemophilus influenzae: analysis of the mutations in QRDRs and assessment of the extent of the AcrAB-TolC-mediated resistance. Cherkaoui A, Gaïa N, Baud D, Leo S, Fischer A, Ruppe E, François P, Schrenzel J. Eur J Clin Microbiol Infect Dis. 2018 Nov;37(11):2201-2210. doi: 10.1007/s10096-018-3362-z. Epub 2018 Aug 25.

Antibiotics stimulate vesicles formation in Staphylococcus aureus in a phage-dependent and independent fashion and via different routes. Andreoni F, Toyofuku M, Menzi C, Kalawong R, Mairpady Shambat S, François P, Zinkernagel AS, Eberl L. Antimicrob Agents Chemother. 2018 Dec 3. pii: AAC.01439-18. doi: 10.1128/AAC.01439-18.

Multiple-Locus Variable Number Tandem Repeat Analysis (MLVA) and Tandem Repeat Sequence Typing (TRST), helpful tools for subtyping Staphylococcus lugdunensis. Dahyot S, Lebeurre J, Argemi X, François P, Lemée L, Prévost G, Pestel-Caron M. Sci Rep. 2018 Aug 3;8(1):11669. doi: 10.1038/s41598-018-30144-y.

Genetic Adaptation of a Mevalonate Pathway Deficient Mutant in Staphylococcus aureus. Reichert S, Ebner P, Bonetti EJ, Luqman A, Nega M, Schrenzel J, Spröer C, Bunk B, Overmann J, Sass P, François P, Götz F. Front Microbiol. 2018 Jul 12;9:1539. doi: 10.3389/fmicb.2018.01539. eCollection 2018.

Colistin heteroresistance and the involvement of the PmrAB regulatory system in Acinetobacter baumannii. Charretier Y, Diene SM, Baud D, Chatellier S, Santiago-Allexant E, van Belkum A, Guigon G, Schrenzel J. Antimicrob Agents Chemother. 2018 Jun 18. pii: AAC.00788-18. doi: 10.1128/AAC.00788-18.

Accuracy of Sensititre YeastOne echinocandins epidemiological cut-off values for identification of FKS mutant Candida albicans and Candida glabrata: a ten year national survey of the Fungal Infection Network of Switzerland (FUNGINOS). Kritikos A, Neofytos D, Khanna N, Schreiber PW, Boggian K, Bille J, Schrenzel J, Mühlethaler K, Zbinden R, Bruderer T, Goldenberger D, Pfyffer G, Conen A, Van Delden C, Zimmerli S, Sanglard D, Bachmann D, Marchetti O, Lamoth F; Fungal Infection Network of Switzerland (FUNGINOS). Clin Microbiol Infect. 2018 Jun 15. pii: S1198-743X(18)30445-2. doi: 10.1016/j.cmi.2018.05.012.

[Microbiota and malnutrition: an overview]. Mareschal J, Schrenzel J, Lazarevic V, Genton L. Rev Med Suisse. 2018 Jun 6;14(610):1194-1199. French.

Fast identification of dermatophytes by MALDI-TOF/MS using direct transfer of fungal cells on ground steel target plates. da Cunha KC, Riat A, Normand AC, Bosshard PP, de Almeida MTG, Piarroux R, Schrenzel J, Fontao L. Mycoses. 2018 May 15. doi: 10.1111/myc.12793.

Differential expression of hemoglobin receptor, HmbR, between carriage and invasive isolates of Neisseria meningitidis contributes to virulence: lessons from a clonal outbreak. Sevestre J, Diene SM, Aouiti-Trabelsi M, Deghmane AE, Tournier I, François P, Caron F, Taha MK. Virulence. 2018 Apr 11:1-18. doi: 10.1080/21505594.2018.1460064.

Fluconazole non-susceptible breakthrough candidemia after prolonged low-dose prophylaxis: a prospective FUNGINOS study. Orasch C, Mertz D, Garbino J, van Delden C, Emonet S, Schrenzel J, Zimmerli S, Damonti L, Mühlethaler K, Imhof A, Ruef C, Fehr J, Zbinden R, Boggian K, Bruderer T, Flückiger U, Conen A, Khanna N, Frei R, Bregenzer T, Lamoth F, Erard V, Bochud PY, Calandra T, Bille J, Marchetti O; Fungal Infection Network of Switzerland (FUNGINOS). J Infect. 2018 Jan 31. pii: S0163-4453(18)30029-X. doi: 10.1016/j.jinf.2017.12.018.

Azole resistance of Aspergillus fumigatus isolates from the environment and the clinic in Switzerland. Riat A, Plojoux J, Gindro K, Schrenzel J, Sanglard D. Antimicrob Agents Chemother. 2018 Feb 5. pii: AAC.02088-17. doi: 10.1128/AAC.02088-17.

Control of Infectious Diseases in the Era of European Clinical Microbiology Laboratory Consolidation: New Challenges and Opportunities for the Patient and for Public Health Surveillance. Vandenberg O, Kozlakidis Z, Schrenzel J, Struelens MJ, Breuer J. Front Med (Lausanne). 2018 Feb 2;5:15. doi: 10.3389/fmed.2018.00015. eCollection 2018.

Messages from the second International Conference on Clinical Metagenomics (ICCMg2). Ruppé E, Schrenzel J. Microbes Infect. 2018 Mar 7. pii: S1286-4579(18)30049-2. doi: 10.1016/j.micinf.2018.02.005.

Transcriptional Modulation of Penicillin-Binding Protein 1b, Outer Membrane Protein P2 and Efflux Pump (AcrAB-TolC) during Heat Stress Is Correlated to Enhanced Bactericidal Action of Imipenem on Non-typeable Haemophilus influenzae. Cherkaoui A, Diene SM, Fischer A, Leo S, François P, Schrenzel J. Front Microbiol. 2018 Jan 12;8:2676. doi: 10.3389/fmicb.2017.02676. eCollection 2017.

A Potential New Human Pathogen Belonging to Helicobacter Genus, Identified in a Bloodstream Infection. van der Mee-Marquet NL, Bénéjat L, Diene SM, Lemaignen A, Gaïa N, Smet A, Haesebrouck F, Cherkaoui A, Ducournau A, Lacomme S, Gontier E, Bernard L, Mégraud F, Goudeau A, Lehours P, François P. Front Microbiol. 2017 Dec 18;8:2533. doi: 10.3389/fmicb.2017.02533. eCollection 2017.

When Bacterial Culture Fails, Metagenomics Can Help: A Case of Chronic Hepatic Brucelloma Assessed by Next-Generation Sequencing. Lazarevic V, Gaïa N, Girard M, Leo S, Cherkaoui A, Renzi G, Emonet S, Jamme S, Ruppé E, Vijgen S, Rubbia-Brandt L, Toso C, Schrenzel J. Front Microbiol. 2018 Jul 17;9:1566. doi: 10.3389/fmicb.2018.01566. eCollection 2018.

A comparison of Sensititre™ Anaerobe MIC plate with ATB ANA® test for the routine susceptibility testing of common anaerobe pathogens. Cherkaoui A, Fischer A, Azam N, Riat A, Schrenzel J. Eur J Clin Microbiol Infect Dis. 2018 Dec;37(12):2279-2284. doi: 10.1007/s10096-018-3369-5. Epub 2018 Sep 6.

Remarques
N/A
Pièces jointes
N/A
5. Décrire succinctement les travaux sur la défense biologique réalisés dans l’installation, y compris le(s) type(s) de micro-organismes(9) et/ou toxines étudiés, et résumer les études en plein air sur les aérosols biologiques.

The Bacteriological Laboratory, which is part of the University Hospitals of Geneva, is the Regional Competence Center for the primary analysis of bacteriological samples suspicious of a bioterror-related background. Protocols for the detection of bacteria causing anthrax, plague, tularemia and brucellosis have been established in close collaboration with the National Reference Center for Anthrax. Furthermore, there is a strong link between the Bacteriological Laboratory and the Genomic Research Laboratory that is almost exclusively executing basic and applied research projects under joint leadership. Translational research is actively promoted through this channel of cooperation.

For further information please visit (website in French):
https://www.hug-ge.ch/laboratoire-bacteriologie

(9) Notamment les virus et prions.