Institut für Mikrobiologie der Bundeswehr (Bundeswehr Institute of Microbiology)

2. 设施位于何处(包括地址和地理位置)?
D-80937 München, Neuherbergstraße 11

(48°12` N, 11°34 ` E)

3. 实验室楼面面积,按封闭级别分列
BL 3 , 67.00 平方米
BL 2 , 1.258.00 平方米

4. 每一设施的组织结构:

(八) 简述设施关于发表论文和报告的政策:

Results are published in scientific journals as well as in reports to the Federal Ministry of Defence and will be presented in national and international scientific meetings.

(九) 提供一份过去12个月内发表的因工作产生并可公开获得的论文和报告的清单。(请填明作者、标题和全部参考说明。)

1.    Aistleitner K, Jeske R, Wölfel R, Wießner A, Kikhney J, Moter A, Stoecker K. (2018). Detection of Coxiella burnetii in heart valve sections by fluorescence in situ hybridization. J Med Micro-biol. Apr;67(4):537-542. doi: 10.1099/jmm.0.000704. Epub 2018 Feb 20.
2.    Andersson MO, Marga G, Banu T, Dobler G, Chitimia-Dobler L (2018). Tick-borne pathogens in tick species infesting humans in Sibiu County, Central Romania. Parasitol Res 117(5):1591-1597. doi: 10.107/s00436-018-5848-0.
3.    Andersson MO, Radbea G, Frangoulidis F, Tomaso H, Rubel F, Nava S, Chitimia-Dobler L (2018). New records and host associations of the tick Ixodes apronophorus and the first detection of Ehrlichia sp. HF in Romania. Parasitol Res 117: 1285-1289. doi: 10.1007/s00436-018-5800-3.
4.    Andersson MO, Tolf C, Tamba P, Stefanache M, Radbea G, Fragoulidis F, Tomaso H, Walden-ström J, Dobler G, Chitimia-Dobler L (2018). Molecular survey of neglected bacterial pathogens reveals an abundant diversity of species and genotypes in ticks collected from animal hosts across Romania. Parasit Vector 11(1):114. doi: 10.1186/s13071-018-2756-1.
5.    Balinandi S, Mugisha L, Johnson B, William K, Teddy N, Bakkes DK, Lutwama JJ, Chitimia-Dobler L, Malmberg M. General and local morphological anomalies in Amblyomma lepidum and Rhipicephalus decoloratus infesting cattle in Uganda. J Med Entomol (accepted).
6.    Becker BV, Seeger T, Beiert T, Antwerpen MH, Palnek A, Port M, Ullmann R (2018). Impact of Ionizing Radiation on Electrophysiological Behavior of Human-induced Ipsc-derived Cardio-myocytes on Multielectrode Arrays.Health Phys. 2018 Jul;115(1):21-28. doi: 10.1097/HP.0000000000000817.
7.    Becker SL, Zange S, Brockmeyer M, Grün U, Halfmann A (2018). Rapid MALDI-TOF-based iden-tification of Brucella melitensis from positive blood culture vials may prevent laboratory-acquired infections. J Hosp Infect. Sep;100(1):117-119. doi: 10.1016/j.jhin.2018.04.008
8.    Bestehorn M, Weigold S, Kern WV, Chitimia-Dobler L, Mackenstedt U, Dobler G, Borde J (2018). Phylogenetics of tick-borne encephalitis virus in endemic foci in the upper Rhine re-gion in France and Germany. PLOS One. 13(10):e0204790. doi: 10.1371/journal.pone.0204790.
9.    Blitvich BJ, Beaty BJ, Blair CD, Brault AC, Dobler G, Drebot MA, Haddow AD, Kramer LD, LaBeaud AD, Monath TP, Mossel EC, Plante K, Powers AM, Tesh RB, Turell MJ, Vasilakis N, Weaver SC (2018). Bunyavirus Taxonomy: limitations and Misconceptions associated with the current ICTV criteria used for species demarcation. Am J Trop Med. 99(1): 11-16. doi: 10.4269/ajtmh.18-0038.
10.    Brockmann SO, Oehme R, Buckenmaier T, Beer M, Jeffery-Smith A, Spannenkrebs M, Haag-Milz S, Wagner-Wiening C, Schlegel C, Fritz J, Zange S, Bestehorn M, Lindau A, Hoffmann D, Tiberi S, Mackenstedt U, Dobler G (2018). A cluster of two human cases of tick-borne encephalitis (TBE) transmitted by unpasteurised goat milk and cheese in Germany, May 2016. Euro Surveill. Apr;23(15). doi: 10.2807/1560-7917.ES.2018.23.15.17-00336.
11.    Brugger K, Walter M, Chitimia-Dobler L, Dobler G, Rubel F (2018). Forecasting next season’s Ixodes ricinus nymphal density: the example of southern Germany 2018. Exp Appl Acarol 75(3):281-288. doi: 10.1007/s10493-018-0267.
12.    Chitimia-Dobler L, Pfeffer T; Dunlop J (2018). Haemaphysalis creatacea a nymph of a new spe-cies of hard tick in Burmese amber. Parasitology 145(5): 1591-1597. doi: 10.1017/s0031182018000537.
13.    Chitimia-Dobler L, Rieß R, Kahl O, Wölfel S, Dobler G, Nava S, Estrada-Pena A (2018). Ixodes inopinatus – occurring outside the Mediterranean region. Ticks Tick Borne Dis. 9(2):196-200. doi: 10.1016/j.ttbdis.2017.09.004.
14.    Dunlop JA, Selden PA, Pfeffer T, Chitimia-Dobler L (2018). A Burmese amber tick wrapped in spider silk. Cretaceous Res 90:136-141. doi: 10.1016/j.cretres.2018.04.013.
15.    Essbauer S, Hofmann M, Kleinemeier C, Wölfel S, Matthee S (2018). Rickettsia diversity in southern Africa: A small mammal perspective. Ticks Tick Borne Dis. 9(2):285-301. doi: 10.1016/j.ttbdis.2017.11.002.
16.    Essbauer S, Hofmann M, Kleinemeier C, Wölfel S, Matthee S. (2018). Rickettsia diversity in southern Africa: A small mammal perspective. Ticks Tick Borne Dis. 2018 Feb;9(2):288-301.
17.    Fischer S, Spierling NG, Heuser E, Kling C, Schmidt S, Rosenfeld UM, Reil D, Imholt C, Jacob J, Ulrich RG, Essbauer S. (2018). High prevalence of Rickettsia helvetica in wild small mammal populations in Germany. Ticks Tick Borne Dis. 2018 Mar;9(3):500-505.
18.    Held J, Schweizer H, Zange S, Panning M, Kern WV, Wagner D (2018). Photo Quiz: Pneumonia and Pyogenic Skin Abscesses in a 79-Year-Old Man. J Clin Microbiol. Jan 24;56(2). pii: e03352-15. doi: 10.1128/JCM.03352-15.
19.    Janowicz A, De Massis F, Ancora M, Cammà C, Patavino C, Battisti A, Prior K, Harmsen D, Scholz H, Zilli K, Sacchini L, Di Giannatale E, Garofolo G. (2018) Core Genome Multilocus Sequence Typing and Single Nucleotide Polymorphism Analysis in the Epidemiology of Brucella melitensis Infections. J Clin Microbiol. 2018 Aug 27;56(9). pii: e00517-18. doi: 10.1128/JCM.00517-18.
20.    Jungwirth N, Puff C, Köster K, Mischke M, Meyer H, Stark A, Thoma B, Zöller G, Seehusen F, Hewicker-Trautwein M, Beineke A, Baumgärtner W and P. Wohlsein (2018). Atypical Cowpox Virus Infection in a Series of Cats. J Comparative Pathology 158, 71-76
21.    Kalinowski J, Ahrens B, Al-Dilaimi A, Winkler A, Wibberg D, Schleenbecker U, Rückert C, Wölfel R and Grass G (2018) Isolation and whole genome analysis of endospore-forming bacteria from heroin. Forensic Science International: Genetics, 32, 1-6. doi: 10.1016/j.fsigen.2017.10.
22.    Kirubakar G, Murugaiyan J, Schaudinn C, Dematheis F, Holland G, Eravci M, Weise C, Roesler U, Lewin A (2018). Proteome Analysis of a M. avium Mutant Exposes a Novel Role of the Bi-functional Protein LysX in the Regulation of Metabolic Activity. J Infect Dis. 2018 Jun 20;218(2):291-299. doi: 10.1093/infdis/jiy100.
23.    Kissenkötter J, Hansen S, Böhlken-Fascher S, Ademowo OG, Oyinloye OE, Bakarey AS, Dobler G, Tappe D, Patel P, Czerny CP, El-Wahed AA (2018). Anal Biochem 544:29-33. doi: 10.1016/j.ab.2017.12.018.
24.    Kurhade C, Schreier S, Lee YP, Zegenhagen L, Hjertqvist M, Dobler G, Kröger A, Överby A (2018). Correlation of severity of human tick-borne encephalitis virus disease and pathogenic-ity in mice. Emerg Infect Dis. 24(9): 1709-1712. doi: 10.3201/eid2409.171825.
25.    Lienemann T, Beyer W, Pelkola K, Rossow H, Rehn A, Antwerpen MH, Grass G (2018). Geno-typing and phylogenetic placement of Bacillus anthracis isolates from Finland, a country with rare anthrax cases. BMC Microbiol. 2018 Sep 3;18(1):102. doi: 10.1186/s12866-018-1250-4.
26.    Lienemann, T, Beyer, W, Pelkola, K, Rossow, H, Rehn, A, Antwerpen, M and Grass, G (2018) Genotyping and phylogenetic placement of Bacillus anthracis isolates from Finland, a country with rare anthrax cases. BMC Microbiol, 18, 102. doi: 10.1186/s12866-018-1250-4
27.    Manzulli V, Fasanella A, Parisi A, Serrecchia L, Donatiello A, Rondinone V, Caruso M, Zange S, Tscherne A, Decaro N, Pedarra C, Galante D (2018). Evaluation of in vitro antimicrobial sus-ceptibility of Bacillus anthracis strains isolated during anthrax outbreaks in Italy from 1984 to 2017 J Vet Sci 2018 Dec 4. [Epub ahead of print]
28.    Pauker VI, Thoma BR, Grass G, Bleichert P, Hanczaruk M, Zöller L, Zange S (2018). Improved discrimination of Bacillus anthracis from Closely Related Species in the Bacillus cereus sensu lato Group based on MALDI-TOF Mass Spectrometry. J Clin Microbiol. Apr 25;56(5). pii: e01900-17. doi: 10.1128/JCM.01900-17.
29.    Pauker, VI, Thoma, BR, Grass, G, Bleichert, P, Hanczaruk, M, Zoller, L and Zange, S (2018) Im-proved discrimination of Bacillus anthracis from closely related species in the Bacillus cereus sensu lato group based on Matrix-Assisted Laser Desorption Ionization-Time of Flight mass spectrometry. J Clin Microbiol, 56. doi: 10.1128/JCM.01900-17.
30.    Petney TN, Saijutha W, Boulanger N, Chitimia-Dobler L, Pfeffer M, Eamudomkarn C, Andrews RH, Ahamad M, Putthasorn N, Muders SV, Petney DA, Robbins RG. Ticks (Argasidae, Ixodidae) and tick-borne diseases of continental Southeast Asia. Zootaxa (accepted)
31.    Ruber, J, Geist, J, Hartmann, M, Millard, A.D., Raeder, U., Zubkov, M., Zwirglmaier, K. (2018). Spatio-temporal distribution pattern of the picocyanobacterium Synechococcus in lakes of different trophic states: a comparison of flow cytometry and sequencing approaches. Hydro-biologia, April 2018, Vol 811, Issue 1, pp77-92
32.    Sahin M, Buyuk F, Baillie L, Wölfel R, Kotorashvili A, Rehn A, Antwerpen MH, Grass G (2018). The identification of novel single nucleotide polymorphisms to assist in mapping the spread of Bacillus anthracis across the Southern Caucasus. Sci Rep. 2018 Jul 26;8(1):11254. doi: 10.1038/s41598-018-29738-3.
33.    Schaumann R, Dallacker-Losensky K, Rosenkranz C, Genzel GH, Stîngu CS, Schellenberger W, Schulz-Stübner S, Rodloff AC, Eschrich K. (2018) Discrimination of Human Pathogen Clostridium Species Especially of the Heterogeneous C. sporogenes and C. botulinum by MALDI-TOF Mass Spectrometry. Curr Microbiol. 2018 Nov;75(11):1506-1515. doi: 10.1007/s00284-018-1552-7. Epub 2018 Aug 17
34.    Schroll A, Theurl I, Georgi E, Zange S, Rettenbacher T, Bellmann-Weiler R, Weiss G (2018). Newly emerging ulceroglandular tularaemia in Western Austria. Ticks Tick Borne Dis. Jul;9(5):1331-1333. doi: 10.1016/j.ttbdis.2018.06.003.
35.    Schroll A, Theurl I, Georgi E, Zange S, Rettenbacher T, Bellmann-Weiler R, Weiss G (2018). Newly emerging ulceroglandular tularaemia in Western Austria. Ticks Tick Borne Dis. 2018 Jul;9(5):1331-1333. doi: 10.1016/j.ttbdis.2018.06.003. Epub 2018 Jun 6.
36.    Speck S, Kern T, Aistleitner K, Dilcher M, Dobler G, Essbauer S (2018). In vitro studies of Rick-ettsia-host cell interactions: Confocal laser scanning microscopy of Rickettsia Helvetica-infected eukaryotic cell lines. PLOS Negl Trop Dis. 12(2):e0006151. doi: 10.1371/journal. Pntd.0006151.
37.    Springer A, Montenegro VM, Schicht S, Wölfel S, Schaper S, Chitimia-Dobler L, Siebert S, Strube C (2018). Detection of Rickettsia monacensis and Rickettsia amblyommatis in ticks collected from dogs in Costa Rica and Nicaragua. Ticks Tick Borne Dis. 9(6):1565-1572. doi: 10.1016/j.ttbdis.2018.08.002.
38.    Springer K, Reuter S, Knüpfer M, Schmauder L, Sänger PA, Felsl A, Fuchs TM (2018): Activity of a Holin-Endolysin System in the Insecticidal Pathogenicity Island of Yersinia enterocolitica. J Bacteriol. 2018 Jul 25;200(16). pii: e00180-18. doi: 10.1128/JB.00180-18. Print 2018 Aug 15.

5. 简述设施内进行的生物战防御工作,包括研究的微生物1 和/或毒素的类型以及生物气雾剂户外研究。

a. Research, development and evaluation of approaches for the rapid detection, identification,  differentiation and typing of Orthopox- , Alpha-, Flavi-, Bunya- and Filoviruses as well as Coxiella, Rickettsia, Burkholderia, Yersinia, Brucella, Bacillus and Francisella spp. using state of the art techniques.

b. Establishment of next generation sequencing techniques, sequence data banks and tools for forensic typing

c. Research, development and evaluation of immunodiagnostics of relevant agents and toxins

d. Studies of the epidemiology, immunopathogenesis and immune response against Francisella tularensis, Bacillus spp., Burkholderia spp., Brucella spp., Yersinia spp., and Flaviviruses

The current programme covers pathogen R I, R II and R III organisms.

No outdoor studies of biological aerosols have been conducted.

(9) 包括病毒和朊粒。