Centre National de Référence pour les Infections Virales Emergentes (National Reference Center for Emerging Viral Infections)

2. Where is it located (include both address and geographical location)?

Centre National de Référence pour les Infections Virales Emergentes, Laboratoire de Virologie, Hôpitaux Universitaires de Genève, Rue Gabrielle Perret-Gentil 4, CH-1205 Genève, Switzerland

N 46° 11' 37.20", E 6° 8' 59.92"

3. Floor area of laboratory areas by containment level
BL 4 , 36.00 SqM
Of note, the BSL4 unit is operational and holds a license for diagnostic purposes only, as follows: “Detection of viruses in clinical samples by molecular and/or serological methods”.
BL 3 , 39.00 SqM
BL 2 , 29.00 SqM
Total laboratory floor area (SqM)

4. The organizational structure of each facility

(viii) Briefly describe the publication policy of the facility

Publication in open literature.

(ix) Provide a list of publicly-available papers and reports resulting from the work published during the previous 12 months. (To include authors, titles and full references)

Novel SARS-CoV-2 variants: the pandemics within the pandemic. 
Boehm E, Kronig I, Neher RA, Eckerle I, Vetter P, Kaiser L; Geneva Centre for Emerging Viral Diseases.
Clin Microbiol Infect. 2021 Aug;27(8):1109-1117. doi: 10.1016/j.cmi.2021.05.022. Epub 2021 May 17.
PMID: 34015535 Free PMC article. Review. 

An action plan for pan-European defence against new SARS-CoV-2 variants. 
Priesemann V, Balling R, Brinkmann MM, Ciesek S, Czypionka T, Eckerle I, Giordano G, Hanson C, Hel Z, Hotulainen P, Klimek P, Nassehi A, Peichl A, Perc M, Petelos E, Prainsack B, Szczurek E.
Lancet. 2021 Feb 6;397(10273):469-470. doi: 10.1016/S0140-6736(21)00150-1. Epub 2021 Jan 21.
PMID: 33485462 Free PMC article. No abstract available. 

Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity. 
Yahav D, Yelin D, Eckerle I, Eberhardt CS, Wang J, Cao B, Kaiser L.
Clin Microbiol Infect. 2021 Mar;27(3):315-318. doi: 10.1016/j.cmi.2020.11.028. Epub 2020 Dec 5.
PMID: 33285276 Free PMC article. No abstract available. 

Immunological Assessment of Pediatric Multisystem Inflammatory Syndrome Related to Coronavirus Disease 2019. 
Grazioli S, Tavaglione F, Torriani G, Wagner N, Rohr M, L'Huillier AG, Leclercq C, Perrin A, Bordessoule A, Beghetti M, Schmid JP, Vavassori S, Perreau M, Eberhardt C, Didierlaurent A, Kaiser L, Eckerle I, Roux-Lombard P, Blanchard-Rohner G.
J Pediatric Infect Dis Soc. 2021 Aug 14;10(6):706-713. doi: 10.1093/jpids/piaa142.
PMID: 33180935 Free PMC article. 

Antibody persistence in the first 6 months following SARS-CoV-2 infection among hospital workers: a prospective longitudinal study. 
L'Huillier AG, Meyer B, Andrey DO, Arm-Vernez I, Baggio S, Didierlaurent A, Eberhardt CS, Eckerle I, Grasset-Salomon C, Huttner A, Posfay-Barbe KM, Royo IS, Pralong JA, Vuilleumier N, Yerly S, Siegrist CA, Kaiser L; Geneva Centre for Emerging Viral Diseases.
Clin Microbiol Infect. 2021 Jan 20;27(5):784.e1-8. doi: 10.1016/j.cmi.2021.01.005. Online ahead of print.
PMID: 33482352 Free PMC article. 

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load in the Upper Respiratory Tract of Children and Adults With Early Acute Coronavirus Disease 2019 (COVID-19). 
Baggio S, L'Huillier AG, Yerly S, Bellon M, Wagner N, Rohr M, Huttner A, Blanchard-Rohner G, Loevy N, Kaiser L, Jacquerioz F, Eckerle I.
Clin Infect Dis. 2021 Jul 1;73(1):148-150. doi: 10.1093/cid/ciaa1157.
PMID: 32761228 Free PMC article. 

Puumala Virus Infection in Family, Switzerland. 
Vetter P, L'Huillier AG, Montalbano MF, Pigny F, Eckerle I, Torriani G, Rothenberger S, Laubscher F, Cordey S, Kaiser L, Schibler M.
Emerg Infect Dis. 2021 Feb;27(2):658-660. doi: 10.3201/eid2702.203770.
PMID: 33496646 Free PMC article. 

Digital COVID Credentials: An Implementation Process. 
Nehme M, Kaiser L, Gillet P, Thevoz P, Stringhini S, Guessous I.
Front Digit Health. 2021 Jun 25;3:594124. doi: 10.3389/fdgth.2021.594124. eCollection 2021.
PMID: 34713082 Free PMC article. No abstract available. 

SARS-CoV-2 rapid diagnostic tests for emerging variants. 
Bekliz M, Adea K, Essaidi-Laziosi M, Sacks JA, Escadafal C, Kaiser L, Eckerle I.
Lancet Microbe. 2021 Aug;2(8):e351. doi: 10.1016/S2666-5247(21)00147-6. Epub 2021 Jun 29.
PMID: 34223400 Free PMC article. No abstract available. 

Paradoxes and Uncertainties of Immunomodulatory Treatments in the Fight Against Coronavirus Disease 2019. 
Kaiser L, Vu DL, Eberhardt CS.
Clin Infect Dis. 2021 Jun 15;72(12):e1144-e1145. doi: 10.1093/cid/ciaa1837.
PMID: 33285564 Free PMC article. No abstract available. 

Viral Loads of SARS-CoV-2 in Young Children. 
L'Huillier AG, Baggio S, Eckerle I.
JAMA Pediatr. 2021 May 1;175(5):529-530. doi: 10.1001/jamapediatrics.2020.5548.
PMID: 33523127 No abstract available. 

Blood virosphere in febrile Tanzanian children. 
Cordey S, Laubscher F, Hartley MA, Junier T, Keitel K, Docquier M, Guex N, Iseli C, Vieille G, Le Mercier P, Gleizes A, Samaka J, Mlaganile T, Kagoro F, Masimba J, Said Z, Temba H, Elbanna GH, Tapparel C, Zanella MC, Xenarios I, Fellay J, D'Acremont V, Kaiser L.
Emerg Microbes Infect. 2021 Dec;10(1):982-993. doi: 10.1080/22221751.2021.1925161.
PMID: 33929935 Free PMC article. 

Perceptions of vaccination certificates among the general population in Geneva, Switzerland. 
Nehme M, Baysson H, Pullen N, Wisniak A, Pennacchio F, Zaballa ME, Fargnoli V, Kaiser L, Hurst S, Burton-Jeangros C, Stringhini S, Guessous I; Specchio-COVID19 study group.
Swiss Med Wkly. 2021 Nov 29;151:w30079. doi: 10.4414/smw.2021.w30079. eCollection 2021 Nov 22.
PMID: 34846113 

SARS-CoV-2 antigen-detecting rapid tests for the delta variant. 
Bekliz M, Adea K, Essaidi-Laziosi M, Sacks JA, Escadafal C, Kaiser L, Eckerle I.
Lancet Microbe. 2022 Feb;3(2):e90. doi: 10.1016/S2666-5247(21)00302-5. Epub 2021 Nov 24.
PMID: 34849494 Free PMC article. No abstract available. 

Seroprevalence of anti-SARS-CoV-2 antibodies after the second pandemic peak. 
Stringhini S, Zaballa ME, Perez-Saez J, Pullen N, de Mestral C, Picazio A, Pennacchio F, Wisniak A, Richard A, Baysson H, Loizeau A, Balavoine JF, Trono D, Pittet D, Posfay-Barbe K, Flahault A, Chappuis F, Kherad O, Vuilleumier N, Kaiser L, Azman AS, Guessous I; Specchio-COVID19 Study Group.
Lancet Infect Dis. 2021 May;21(5):600-601. doi: 10.1016/S1473-3099(21)00054-2. Epub 2021 Feb 1.
PMID: 33539733 Free PMC article. No abstract available. 

Quantification of the spread of SARS-CoV-2 variant B.1.1.7 in Switzerland. 
Chen C, Nadeau SA, Topolsky I, Manceau M, Huisman JS, Jablonski KP, Fuhrmann L, Dreifuss D, Jahn K, Beckmann C, Redondo M, Noppen C, Risch L, Risch M, Wohlwend N, Kas S, Bodmer T, Roloff T, Stange M, Egli A, Eckerle I, Kaiser L, Denes R, Feldkamp M, Nissen I, Santacroce N, Burcklen E, Aquino C, de Gouvea AC, Moccia MD, Grüter S, Sykes T, Opitz L, White G, Neff L, Popovic D, Patrignani A, Tracy J, Schlapbach R, Dermitzakis ET, Harshman K, Xenarios I, Pegeot H, Cerutti L, Penet D, Blin A, Elies M, Althaus CL, Beisel C, Beerenwinkel N, Ackermann M, Stadler T.
Epidemics. 2021 Dec;37:100480. doi: 10.1016/j.epidem.2021.100480. Epub 2021 Aug 9.
PMID: 34488035 Free PMC article. 

Prognosis of Laboratory-Confirmed Influenza and Respiratory Syncytial Virus in Acute Heart Failure. 
Carballo D, Garin N, Stirnemann J, Mamin A, Prendki V, Meyer P, Marti C, Mach F, Reny JL, Serratrice J, Kaiser L, Carballo S.
J Clin Med. 2021 Sep 30;10(19):4546. doi: 10.3390/jcm10194546.
PMID: 34640562 Free PMC article. 

Insights into household transmission of SARS-CoV-2 from a population-based serological survey. 
Bi Q, Lessler J, Eckerle I, Lauer SA, Kaiser L, Vuilleumier N, Cummings DAT, Flahault A, Petrovic D, Guessous I, Stringhini S, Azman AS; SEROCoV-POP Study Group.
Nat Commun. 2021 Jun 15;12(1):3643. doi: 10.1038/s41467-021-23733-5.
PMID: 34131124 Free PMC article. 

Socioeconomically Disadvantaged Neighborhoods Face Increased Persistence of SARS-CoV-2 Clusters. 
De Ridder D, Sandoval J, Vuilleumier N, Azman AS, Stringhini S, Kaiser L, Joost S, Guessous I.
Front Public Health. 2021 Jan 27;8:626090. doi: 10.3389/fpubh.2020.626090. eCollection 2020.
PMID: 33614571 Free PMC article. 

Viral co-infections among SARS-CoV-2-infected children and infected adult household contacts. 
Pigny F, Wagner N, Rohr M, Mamin A, Cherpillod P, Posfay-Barbe KM, Kaiser L, Eckerle I, L'Huillier AG; Geneva Pediatric COVID Group.
Eur J Pediatr. 2021 Jun;180(6):1991-1995. doi: 10.1007/s00431-021-03947-x. Epub 2021 Jan 27.
PMID: 33502627 Free PMC article. 

Serology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland. 
Perez-Saez J, Lauer SA, Kaiser L, Regard S, Delaporte E, Guessous I, Stringhini S, Azman AS; Serocov-POP Study Group.
Lancet Infect Dis. 2021 Apr;21(4):e69-e70. doi: 10.1016/S1473-3099(20)30584-3. Epub 2020 Jul 14.
PMID: 32679085 Free PMC article. No abstract available. 

Persistence of anti-SARS-CoV-2 antibodies: immunoassay heterogeneity and implications for serosurveillance. 
Perez-Saez J, Zaballa ME, Yerly S, Andrey DO, Meyer B, Eckerle I, Balavoine JF, Chappuis F, Pittet D, Trono D, Kherad O, Vuilleumier N, Kaiser L, Guessous I, Stringhini S, Azman AS; Specchio-COVID19 Study Group.
Clin Microbiol Infect. 2021 Nov;27(11):1695.e7-1695.e12. doi: 10.1016/j.cmi.2021.06.040. Epub 2021 Jul 7.
PMID: 34245905 Free PMC article. 

Estimating clinical SARS-CoV-2 infectiousness in Vero E6 and primary airway epithelial cells. 
Essaidi-Laziosi M, Perez Rodriguez FJ, Hulo N, Jacquerioz F, Kaiser L, Eckerle I.
Lancet Microbe. 2021 Nov;2(11):e571. doi: 10.1016/S2666-5247(21)00216-0. Epub 2021 Aug 27.
PMID: 34485956 Free PMC article. No abstract available. 

Treatment of COVID-19 Pneumonia: the Case for Placenta-derived Cell Therapy. 
Berishvili E, Kaiser L, Cohen M, Berney T, Scholz H, Floisand Y, Mattsson J.
Stem Cell Rev Rep. 2021 Feb;17(1):63-70. doi: 10.1007/s12015-020-10004-x.
PMID: 32696426 Free PMC article. 

Antibody responses to SARS-CoV2 vaccination in allogeneic hematopoietic stem cell transplant recipients. 
Mamez AC, Pradier A, Giannotti F, Petitpas A, Urdiola MF, Vu DL, Masouridi-Levrat S, Morin S, Dantin C, Clerc-Renaud D, Eberhardt CS, Kaiser L, Simonetta F, Chalandon Y.
Bone Marrow Transplant. 2021 Dec;56(12):3094-3096. doi: 10.1038/s41409-021-01466-9. Epub 2021 Sep 28.
PMID: 34584239 Free PMC article. No abstract available. 

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Viral Load Kinetics in Symptomatic Children, Adolescents, and Adults. 
Bellon M, Baggio S, Jacquerioz Bausch F, Spechbach H, Salamun J, Genecand C, Tardin A, Kaiser L, L'Huillier AG, Eckerle I.
Clin Infect Dis. 2021 Sep 15;73(6):e1384-e1386. doi: 10.1093/cid/ciab396.
PMID: 33949655 Free PMC article. 

Clinical, virologic and immunologic features of a mild case of SARS-CoV-2 reinfection. 
Vetter P, Cordey S, Schibler M, Vieux L, Despres L, Laubscher F, Andrey DO, Martischang R, Harbarth S, Cuvelier C, Bekliz M, Eckerle I, Siegrist CA, Didierlaurent AM, Eberhardt CS, Meyer B, Kaiser L; Geneva Center for Emerging Viral Diseases.
Clin Microbiol Infect. 2021 Feb 20;27(5):791.e1-4. doi: 10.1016/j.cmi.2021.02.010. Online ahead of print.
PMID: 33618012 Free PMC article. 

Diagnostic accuracy of Panbio rapid antigen tests on oropharyngeal swabs for detection of SARS-CoV-2. 
Ngo Nsoga MT, Kronig I, Perez Rodriguez FJ, Sattonnet-Roche P, Da Silva D, Helbling J, Sacks JA, de Vos M, Boehm E, Gayet-Ageron A, Berger A, Jacquerioz-Bausch F, Chappuis F, Kaiser L, Schibler M, Renzoni A, Eckerle I.
PLoS One. 2021 Jun 24;16(6):e0253321. doi: 10.1371/journal.pone.0253321. eCollection 2021.
PMID: 34166410 Free PMC article. Clinical Trial. 

Head-to-Head Evaluation of Five Automated SARS-CoV-2 Serology Immunoassays in Various Prevalence Settings. 
Andrey DO, Yerly S, Meyer B, Arm-Vernez I, Roux-Lombard P, Togni G, Guessous I, Spechbach H, Stringhini S, Agoritsas T, Stirnemann J, Reny JL, Siegrist CA, Eckerle I, Kaiser L, Vuilleumier N.
J Clin Med. 2021 Apr 10;10(8):1605. doi: 10.3390/jcm10081605.
PMID: 33920076 Free PMC article. 

Molecular epidemiology of respiratory syncytial virus in children in sub-Saharan Africa. 
Ihling CM, Schnitzler P, Heinrich N, Mangu C, Sudi L, Souares A, Gies S, Sié A, Coulibaly B, Ouédraogo AT, Mordmüller B, Held J, Adegnika AA, Fernandes JF, Eckerle I, May J, Hogan B, Eibach D, Tabatabai J.
Trop Med Int Health. 2021 Jul;26(7):810-822. doi: 10.1111/tmi.13573. Epub 2021 Mar 28.
PMID: 33683751 

Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland. 
Stringhini S, Zaballa ME, Pullen N, de Mestral C, Perez-Saez J, Dumont R, Picazio A, Pennacchio F, Dibner Y, Yerly S, Baysson H, Vuilleumier N, Balavoine JF, Bachmann D, Trono D, Pittet D, Chappuis F, Kherad O, Kaiser L, Azman AS; SEROCoV-WORK + Study Group, Guessous I.
Nat Commun. 2021 Jun 8;12(1):3455. doi: 10.1038/s41467-021-23796-4.
PMID: 34103517 Free PMC article. 

A high-throughput microfluidic nanoimmunoassay for detecting anti-SARS-CoV-2 antibodies in serum or ultralow-volume blood samples. 
Swank Z, Michielin G, Yip HM, Cohen P, Andrey DO, Vuilleumier N, Kaiser L, Eckerle I, Meyer B, Maerkl SJ.
Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2025289118. doi: 10.1073/pnas.2025289118.
PMID: 33945500 Free PMC article. 

Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta. 
Ulrich L, Halwe NJ, Taddeo A, Ebert N, Schön J, Devisme C, Trüeb BS, Hoffmann B, Wider M, Fan X, Bekliz M, Essaidi-Laziosi M, Schmidt ML, Niemeyer D, Corman VM, Kraft A, Godel A, Laloli L, Kelly JN, Calderon BM, Breithaupt A, Wylezich C, Berenguer Veiga I, Gultom M, Osman S, Zhou B, Adea K, Meyer B, Eberhardt CS, Thomann L, Gsell M, Labroussaa F, Jores J, Summerfield A, Drosten C, Eckerle IA, Wentworth DE, Dijkman R, Hoffmann D, Thiel V, Beer M, Benarafa C.
Nature. 2022 Feb;602(7896):307-313. doi: 10.1038/s41586-021-04342-0. Epub 2021 Dec 22.
PMID: 34937050 Free PMC article. 

SARS-CoV-2 infection as a trigger of humoral response against apolipoprotein A-1. 
Pagano S, Yerly S, Meyer B, Juillard C, Suh N, Le Terrier C, Daguer JP, Farrera-Soler L, Barluenga S, Piumatti G, Hartley O, Lemaitre B, Eberhardt CS, Siegrist CA, Eckerle I, Stringhini S, Guessous I, Kaiser L, Pugin J, Winssinger N, Vuilleumier N.
Eur J Clin Invest. 2021 Nov;51(11):e13661. doi: 10.1111/eci.13661. Epub 2021 Aug 4.
PMID: 34324704 Free PMC article. 

Robust innate responses to SARS-CoV-2 in children resolve faster than in adults without compromising adaptive immunity. 
Vono M, Huttner A, Lemeille S, Martinez-Murillo P, Meyer B, Baggio S, Sharma S, Thiriard A, Marchant A, Godeke GJ, Reusken C, Alvarez C, Perez-Rodriguez F, Eckerle I, Kaiser L, Loevy N, Eberhardt CS, Blanchard-Rohner G, Siegrist CA, Didierlaurent AM.
Cell Rep. 2021 Oct 5;37(1):109773. doi: 10.1016/j.celrep.2021.109773. Epub 2021 Sep 15.
PMID: 34587479 Free PMC article. 

Sero-molecular epidemiology of hepatitis E virus in pigs and human contacts in Ghana. 
Yeboah R, Sylverken AA, Owusu M, El-Duah P, Burimuah V, Frimpong Y, Lamptey J, Eckerle I, Meyer B, Antwi C, Agbenyaga O, Folitse R, Emikpe B, Oppong SK, Adu-Sarkodie Y, Drosten C.
One Health Outlook. 2021 Jun 22;3(1):13. doi: 10.1186/s42522-021-00043-w.
PMID: 34154674 Free PMC article. 

Analytical Evaluation of Visby Medical RT-PCR Portable Device for Rapid Detection of SARS-CoV-2. 
Renzoni A, Perez F, Ngo Nsoga MT, Yerly S, Boehm E, Gayet-Ageron A, Kaiser L, Schibler M.
Diagnostics (Basel). 2021 Apr 29;11(5):813. doi: 10.3390/diagnostics11050813.
PMID: 33947153 Free PMC article. 

Diagnostic Accuracy of SARS-CoV-2 Rapid Antigen Detection Testing in Symptomatic and Asymptomatic Children in the Clinical Setting. 
L'Huillier AG, Lacour M, Sadiku D, Gadiri MA, De Siebenthal L, Schibler M, Eckerle I, Pinösch S, Kaiser L, Gervaix A, Glangetas A, Galetto-Lacour A, Lacroix L.
J Clin Microbiol. 2021 Aug 18;59(9):e0099121. doi: 10.1128/JCM.00991-21. Epub 2021 Aug 18.
PMID: 34190574 Free PMC article. 

SARS-CoV-2 Evolution among Oncological Population: In-Depth Virological Analysis of a Clinical Cohort. 
Laubscher F, Cordey S, Friedlaender A, Schweblin C, Noetzlin S, Simand PF, Bordry N, De Sousa F, Pigny F, Baggio S, Getaz L, Dietrich PY, Kaiser L, Vu DL.
Microorganisms. 2021 Oct 14;9(10):2145. doi: 10.3390/microorganisms9102145.
PMID: 34683466 Free PMC article. 

RSV and HMPV Infections in 3D Tissue Cultures: Mechanisms Involved in Virus-Host and Virus-Virus Interactions. 
Geiser J, Boivin G, Huang S, Constant S, Kaiser L, Tapparel C, Essaidi-Laziosi M.
Viruses. 2021 Jan 19;13(1):139. doi: 10.3390/v13010139.
PMID: 33478119 Free PMC article. 

External Quality Assessment of SARS-CoV-2 Sequencing: an ESGMD-SSM Pilot Trial across 15 European Laboratories. 
Wegner F, Roloff T, Huber M, Cordey S, Ramette A, Gerth Y, Bertelli C, Stange M, Seth-Smith HMB, Mari A, Leuzinger K, Cerutti L, Harshman K, Xenarios I, Le Mercier P, Bittel P, Neuenschwander S, Opota O, Fuchs J, Panning M, Michel C, Hallin M, Demuyser T, De Mendonca R, Savelkoul P, Dingemans J, van der Veer B, Boers SA, Claas ECJ, Coolen JPM, Melchers WJG, Gunell M, Kallonen T, Vuorinen T, Hakanen AJ, Bernhoff E, Hetland MAK, Golan Berman H, Adar S, Moran-Gilad J, Wolf DG, Leib SL, Nolte O, Kaiser L, Schmutz S, Kufner V, Zaheri M, Trkola A, Aamot HV, Hirsch HH, Greub G, Egli A.
J Clin Microbiol. 2022 Jan 19;60(1):e0169821. doi: 10.1128/JCM.01698-21. Epub 2021 Nov 10.
PMID: 34757834 Free PMC article. 

A public health strategy for SARS-CoV-2, grounded in science, should guide Swiss schools through the coming winter. 
Keiser O, Agoritsas T, Althaus CL, Azman AS, de Quervain D, Flahault A, Goutaki M, Merglen A, Eckerle I.
Swiss Med Wkly. 2021 Oct 14;151:w30086. doi: 10.4414/smw.2021.w30086. eCollection 2021 Oct 11.
PMID: 34652090 No abstract available. 

Non-Toxic Virucidal Macromolecules Show High Efficacy Against Influenza Virus Ex Vivo and In Vivo. 
Kocabiyik O, Cagno V, Silva PJ, Zhu Y, Sedano L, Bhide Y, Mettier J, Medaglia C, Da Costa B, Constant S, Huang S, Kaiser L, Hinrichs WLJ, Huckriede A, Le Goffic R, Tapparel C, Stellacci F.
Adv Sci (Weinh). 2020 Dec 14;8(3):2001012. doi: 10.1002/advs.202001012. eCollection 2021 Feb.
PMID: 33552848 Free PMC article. 

Invasive Mold Infections in Allogeneic Hematopoietic Cell Transplant Recipients in 2020: Have We Made Enough Progress? 
Roth RS, Masouridi-Levrat S, Chalandon Y, Mamez AC, Giannotti F, Riat A, Fischer A, Poncet A, Glampedakis E, Van Delden C, Kaiser L, Neofytos D.
Open Forum Infect Dis. 2021 Nov 29;9(1):ofab596. doi: 10.1093/ofid/ofab596. eCollection 2022 Jan.
PMID: 34993259 Free PMC article. 

Seroprevalence of anti-SARS-CoV-2 IgG antibodies, risk factors for infection and associated symptoms in Geneva, Switzerland: a population-based study. 
Richard A, Wisniak A, Perez-Saez J, Garrison-Desany H, Petrovic D, Piumatti G, Baysson H, Picazio A, Pennacchio F, De Ridder D, Chappuis F, Vuilleumier N, Low N, Hurst S, Eckerle I, Flahault A, Kaiser L, Azman AS, Guessous I, Stringhini S.
Scand J Public Health. 2022 Feb;50(1):124-135. doi: 10.1177/14034948211048050. Epub 2021 Oct 19.
PMID: 34664529 Free PMC article. 

Occupational risk of SARS-CoV-2 infection and reinfection during the second pandemic surge: a cohort study. 
Leidi A, Berner A, Dumont R, Dubos R, Koegler F, Piumatti G, Vuilleumier N, Kaiser L, Balavoine JF, Trono D, Pittet D, Chappuis F, Kherad O, Courvoisier DS, Azman AS, Zaballa ME, Guessous I, Stringhini S; SEROCoV-WORK+ study group.
Occup Environ Med. 2022 Feb;79(2):116-119. doi: 10.1136/oemed-2021-107924. Epub 2021 Dec 8.
PMID: 34880045 

Robust T cell responses in anti-CD20 treated patients following COVID-19 vaccination: a prospective cohort study. 
Madelon N, Lauper K, Breville G, Sabater Royo I, Goldstein R, Andrey DO, Grifoni A, Sette A, Kaiser L, Siegrist CA, Finckh A, Lalive PH, Didierlaurent AM, Eberhardt CS.
Clin Infect Dis. 2021 Nov 17:ciab954. doi: 10.1093/cid/ciab954. Online ahead of print.
PMID: 34791081 Free PMC article. 

Diagnostic accuracy of two commercial SARS-CoV-2 antigen-detecting rapid tests at the point of care in community-based testing centers. 
Berger A, Nsoga MTN, Perez-Rodriguez FJ, Aad YA, Sattonnet-Roche P, Gayet-Ageron A, Jaksic C, Torriani G, Boehm E, Kronig I, Sacks JA, de Vos M, Bausch FJ, Chappuis F, Renzoni A, Kaiser L, Schibler M, Eckerle I.
PLoS One. 2021 Mar 31;16(3):e0248921. doi: 10.1371/journal.pone.0248921. eCollection 2021.
PMID: 33788882 Free PMC article. 

Chlamydia pneumoniae and Mycoplasma pneumoniae in children with cystic fibrosis: impact on bacterial respiratory microbiota diversity. 
Pittet LF, Bertelli C, Scherz V, Rochat I, Mardegan C, Brouillet R, Jaton K, Mornand A, Kaiser L, Posfay-Barbe K, Asner SA, Greub G.
Pathog Dis. 2021 Jan 6;79(1):ftaa074. doi: 10.1093/femspd/ftaa074.
PMID: 33247928 Free PMC article. 

Sensitivity of nasopharyngeal, oropharyngeal, and nasal wash specimens for SARS-CoV-2 detection in the setting of sampling device shortage. 
Calame A, Mazza L, Renzoni A, Kaiser L, Schibler M.
Eur J Clin Microbiol Infect Dis. 2021 Feb;40(2):441-445. doi: 10.1007/s10096-020-04039-8. Epub 2020 Sep 17.
PMID: 32939576 Free PMC article. 

Longitudinal Analysis of Inflammatory Response to SARS-CoV-2 in the Upper Respiratory Tract Reveals an Association with Viral Load, Independent of Symptoms. 
Vu DL, Martinez-Murillo P, Pigny F, Vono M, Meyer B, Eberhardt CS, Lemeille S, Von Dach E, Blanchard-Rohner G, Eckerle I, Huttner A, Siegrist CA, Kaiser L, Didierlaurent AM.
J Clin Immunol. 2021 Nov;41(8):1723-1732. doi: 10.1007/s10875-021-01134-z. Epub 2021 Sep 28.
PMID: 34581925 Free PMC article. 

Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study. 
Wisniak A, Menon LK, Dumont R, Pullen N, Regard S, Dubos R, Zaballa ME, Baysson H, Courvoisier D, Kaiser L, Pittet D, Azman AS, Stringhini S, Guessous I, Balavoine JF, Kherad O, The SEROCoV-Work Study Group.
Viruses. 2021 Dec 28;14(1):43. doi: 10.3390/v14010043.
PMID: 35062247 Free PMC article. 

Prevalence of Immunoglobulin G (IgG) Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Evaluation of a Rapid MEDsan IgG Test in Children Seeking Medical Care. 
Posfay-Barbe KM, Andrey DO, Virzi J, Cohen P, Pigny F, Goncalves AR, Pinosch S, Lacroix L, Stringhini S, Kaiser L, Vuilleumier N, L'Huillier AG.
Clin Infect Dis. 2021 Apr 8;72(7):e192-e195. doi: 10.1093/cid/ciaa1702.
PMID: 33161427 Free PMC article. 

Seroprevalence of anti-SARS-CoV-2 antibodies 6 months into the vaccination campaign in Geneva, Switzerland, 1 June to 7 July 2021. 
Stringhini S, Zaballa ME, Pullen N, Perez-Saez J, de Mestral C, Loizeau AJ, Lamour J, Pennacchio F, Wisniak A, Dumont R, Baysson H, Richard V, Lorthe E, Semaani C, Balavoine JF, Pittet D, Vuilleumier N, Chappuis F, Kherad O, Azman AS, Posfay-Barbe K, Kaiser L, Guessous I; Specchio-COVID19 study group.
Euro Surveill. 2021 Oct;26(43):2100830. doi: 10.2807/1560-7917.ES.2021.26.43.2100830.
PMID: 34713799 Free PMC article. 

Frequency and causes of antifungal treatment changes in allogeneic haematopoïetic cell transplant recipients with invasive mould infections. 
Roth RS, Masouridi-Levrat S, Giannotti F, Mamez AC, Glambedakis E, Lamoth F, Bochud PY, Erard V, Emonet S, Van Delden C, Kaiser L, Chalandon Y, Neofytos D.
Mycoses. 2022 Feb;65(2):199-210. doi: 10.1111/myc.13416. Epub 2021 Dec 29.
PMID: 34936143 

Ninety-day outcome of patients with severe COVID-19 treated with tocilizumab - a single centre cohort study. 
Sava M, Sommer G, Daikeler T, Woischnig AK, Martinez AE, Leuzinger K, Hirsch HH, Erlanger T, Wiencierz A, Bassetti S, Tamm M, Tschudin-Sutter S, Stoeckle M, Pargger H, Siegemund M, Boss R, Zimmer G, Vu DL, Kaiser L, Dell-Kuster S, Weisser M, Battegay M, Hostettler K, Khanna N.
Swiss Med Wkly. 2021 Aug 10;151:w20550. doi: 10.4414/smw.2021.20550. eCollection 2021 Aug 2.
PMID: 34375986 

Post-exposure Lopinavir-Ritonavir Prophylaxis versus Surveillance for Individuals Exposed to SARS-CoV-2: The COPEP Pragmatic Open-Label, Cluster Randomized Trial. 
Labhardt ND, Smit M, Petignat I, Perneger T, Marinosci A, Ustero P, Diniz Ribeiro MP, Ragozzino S, Nicoletti GJ, Faré PB, Andrey DO, Jacquerioz F, Lebowitz D, Agoritsas T, Meyer B, Spechbach H, Salamun J, Guessous I, Chappuis F, Kaiser L, Decosterd LA, Grinsztejn B, Bernasconi E, Cardoso SW, Calmy A, Team FTCS.
EClinicalMedicine. 2021 Dec;42:101188. doi: 10.1016/j.eclinm.2021.101188. Epub 2021 Nov 6.
PMID: 34778734 Free PMC article. 

Feasibility and safety of rVSV-ZEBOV vaccination of humanitarian health workers against Ebola virus disease: an observational study. 
Carnino L, Vetter P, Peyraud N, Aebischer-Perone S, Chappuis F, Huttner A, Kaiser L, Eperon G.
J Travel Med. 2021 Dec 29;28(8):taab086. doi: 10.1093/jtm/taab086.
PMID: 34128975 

Case Report: Stepwise Anti-Inflammatory and Anti-SARS-CoV-2 Effects Following Convalescent Plasma Therapy With Full Clinical Recovery. 
Zimmerli A, Monti M, Fenwick C, Eckerle I, Beigelman-Aubry C, Pellaton C, Jaton K, Dumas D, Stamm GM, Infanti L, Andreu-Ullrich H, Germann D, Mean M, Vollenweider P, Stadelmann R, Prella M, Comte D, Guery B, Gachoud D, Rufer N.
Front Immunol. 2021 Apr 21;12:613502. doi: 10.3389/fimmu.2021.613502. eCollection 2021.
PMID: 33968017 Free PMC article. 

Unexpected associations between respiratory viruses and bacteria with Pulmonary Function Testing in children suffering from Cystic Fibrosis (MUCOVIB study). 
Scherz V, Caruana G, Taffé P, Brouillet R, Bertelli C, Jaton-Ogay K, Fougère Y, Posfay-Barbe KM, Mornand A, Rochat-Guignard I, Mamin A, Kaiser L, Greub G, Asner SA.
J Cyst Fibros. 2021 Oct 29:S1569-1993(21)02103-2. doi: 10.1016/j.jcf.2021.10.001. Online ahead of print.
PMID: 34756681 

Novel Use of Capture-Recapture Methods to Estimate Completeness of Contact Tracing during an Ebola Outbreak, Democratic Republic of the Congo, 2018-2020. 
Polonsky JA, Böhning D, Keita M, Ahuka-Mundeke S, Nsio-Mbeta J, Abedi AA, Mossoko M, Estill J, Keiser O, Kaiser L, Yoti Z, Sangnawakij P, Lerdsuwansri R, Vilas VJDR.
Emerg Infect Dis. 2021 Dec;27(12):3063-3072. doi: 10.3201/eid2712.204958.
PMID: 34808076 Free PMC article. 

SARS-CoV-2 testing strategy: A comparison of restricted and extended strategies in a Swiss outpatient cohort from the community and hospital employees. 
Baggio S, Spechbach H, Vernaz N, Guessous I, Gétaz L, Kaiser L, Chappuis F, Salamun J, Jacquerioz F.
PLoS One. 2021 Apr 22;16(4):e0250021. doi: 10.1371/journal.pone.0250021. eCollection 2021.
PMID: 33886627 Free PMC article. 

Identifying adults with acute rhinosinusitis in primary care that benefit most from antibiotics: protocol of an individual patient data meta-analysis using multivariable risk prediction modelling. 
Venekamp RP, Hoogland J, van Smeden M, Rovers MM, De Sutter AI, Merenstein D, van Essen GA, Kaiser L, Liira H, Little P, Bucher HC, Reitsma JB.
BMJ Open. 2021 Jul 1;11(7):e047186. doi: 10.1136/bmjopen-2020-047186.
PMID: 34210729 Free PMC article. 

SARS-CoV-2 N501Y Introductions and Transmissions in Switzerland from Beginning of October 2020 to February 2021-Implementation of Swiss-Wide Diagnostic Screening and Whole Genome Sequencing. 
Goncalves Cabecinhas AR, Roloff T, Stange M, Bertelli C, Huber M, Ramette A, Chen C, Nadeau S, Gerth Y, Yerly S, Opota O, Pillonel T, Schuster T, Metzger CMJA, Sieber J, Bel M, Wohlwend N, Baumann C, Koch MC, Bittel P, Leuzinger K, Brunner M, Suter-Riniker F, Berlinger L, Søgaard KK, Beckmann C, Noppen C, Redondo M, Steffen I, Seth-Smith HMB, Mari A, Lienhard R, Risch M, Nolte O, Eckerle I, Martinetti Lucchini G, Hodcroft EB, Neher RA, Stadler T, Hirsch HH, Leib SL, Risch L, Kaiser L, Trkola A, Greub G, Egli A.
Microorganisms. 2021 Mar 25;9(4):677. doi: 10.3390/microorganisms9040677.
PMID: 33806013 Free PMC article. 

Development and validation of the OUTCoV score to predict the risk of hospitalisation among patients with SARS-CoV-2 infection in ambulatory settings: a prospective cohort study. 
Jacquerioz F, Baggio S, Gayet-Ageron A, Chappuis F, Getaz L, Guessous I, Kaiser L, Vernaz N, Yerly S, Salamun J, Spechbach H.
BMJ Open. 2021 Jun 18;11(6):e044242. doi: 10.1136/bmjopen-2020-044242.
PMID: 34145007 Free PMC article. 

Inhibition of interferon I induction by non-structural protein NSs of Puumala virus and other vole-associated orthohantaviruses: phenotypic plasticity of the protein and potential functional domains. 
Binder F, Gallo G, Bendl E, Eckerle I, Ermonval M, Luttermann C, Ulrich RG.
Arch Virol. 2021 Nov;166(11):2999-3012. doi: 10.1007/s00705-021-05159-y. Epub 2021 Aug 13.
PMID: 34389893 Free PMC article. 

Network Analysis of Outpatients to Identify Predictive Symptoms and Combinations of Symptoms Associated With Positive/Negative SARS-CoV-2 Nasopharyngeal Swabs. 
Spechbach H, Jacquerioz F, Prendki V, Kaiser L, Smit M, Calmy A, Chappuis F, Guessous I, Salamun J, Baggio S.
Front Med (Lausanne). 2021 Jul 20;8:685124. doi: 10.3389/fmed.2021.685124. eCollection 2021.
PMID: 34355004 Free PMC article. 

Detection of Spatiotemporal Clusters of COVID-19-Associated Symptoms and Prevention Using a Participatory Surveillance App: Protocol for the @choum Study. 
De Ridder D, Loizeau AJ, Sandoval JL, Ehrler F, Perrier M, Ritch A, Violot G, Santolini M, Greshake Tzovaras B, Stringhini S, Kaiser L, Pradeau JF, Joost S, Guessous I.
JMIR Res Protoc. 2021 Oct 6;10(10):e30444. doi: 10.2196/30444.
PMID: 34449403 Free PMC article. 

Epidemiological, clinical, and public health response characteristics of a large outbreak of diphtheria among the Rohingya population in Cox's Bazar, Bangladesh, 2017 to 2019: A retrospective study. 
Polonsky JA, Ivey M, Mazhar MKA, Rahman Z, le Polain de Waroux O, Karo B, Jalava K, Vong S, Baidjoe A, Diaz J, Finger F, Habib ZH, Halder CE, Haskew C, Kaiser L, Khan AS, Sangal L, Shirin T, Zaki QA, Salam MA, White K.
PLoS Med. 2021 Apr 1;18(4):e1003587. doi: 10.1371/journal.pmed.1003587. eCollection 2021 Apr.
PMID: 33793554 Free PMC article. 

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) seroconversion and occupational exposure of employees at a Swiss university hospital: A large longitudinal cohort study. 
Martischang R, Iten A, Arm I, Abbas M, Meyer B, Yerly S, Eckerle I, Pralong J, Sauser J, Suard JC, Kaiser L, Pittet D, Harbarth S.
Infect Control Hosp Epidemiol. 2021 Mar 19:1-8. doi: 10.1017/ice.2021.117. Online ahead of print.
PMID: 33736734 Free PMC article. 

Burden, epidemiology, and outcomes of microbiologically confirmed respiratory viral infections in solid organ transplant recipients: a nationwide, multi-season prospective cohort study. 
Mombelli M, Lang BM, Neofytos D, Aubert JD, Benden C, Berger C, Boggian K, Egli A, Soccal PM, Kaiser L, Hirzel C, Pascual M, Koller M, Mueller NJ, van Delden C, Hirsch HH, Manuel O; Swiss Transplant Cohort Study.
Am J Transplant. 2021 May;21(5):1789-1800. doi: 10.1111/ajt.16383. Epub 2020 Nov 28.
PMID: 33131188 

Effects of antibiotic duration on the intestinal microbiota and resistome: The PIRATE RESISTANCE project, a cohort study nested within a randomized trial. 
Leo S, Lazarevic V, von Dach E, Kaiser L, Prendki V, Schrenzel J, Huttner BD, Huttner A.
EBioMedicine. 2021 Sep;71:103566. doi: 10.1016/j.ebiom.2021.103566. Epub 2021 Sep 4.
PMID: 34492446 Free PMC article. Clinical Trial. 

5. Briefly describe the biological defence work carried out at the facility, including type(s) of micro-organisms(9) and/or toxins studied, as well as outdoor studies of biological aerosols.

The National Reference Center for Emerging Viral Diseases (CRIVE/NAVI) is a national reference laboratory by order of the Federal Office of Public Health. Its task is the detection of emerging and re-emerging viruses of all biosafety levels, especially hemorrhagic fever viruses and smallpox virus. The BSL4 unit is approved for diagnostic purposes only, which does not allow any culturing or enrichment of such viruses. The National Reference Center for Emerging Viral Diseases is part of the Laboratory of Virology (LV) at the University Hospitals of Geneva. Since January 1st, 2018, the CRIVE acts also as WHO National Center for Measles and Rubella.

Since the beginning of 2020, the CRIVE has been performing about 200’000 SARS-CoV-2 screening PCR and many thousands serologies. Currently, the CRIVE also performs Sanger and NGS sequencing on SARS-CoV-2 genomes for identification of variants.

The LV performs the analysis of many viruses impacting the human health as done in most of the hospitals (HIV, Hepatitis, CMV, EBV, respiratory and enteric viruses, etc.). LV does most of the viral analysis needed by an university hospital.

LV also hosts the Swiss National Center for Influenza.

For further information please visit (website in French):

(9) Including viruses and prions.