2. Where is it located (include both address and geographical location)?
N 47° 22' 36.20", E 8° 33' 11.18"
4. The organizational structure of each facility
(ii) Division of personnel
(iii) Division of personnel by category
Microbiology (bacteriology / mycology).
Cantons of Appenzell Ausserrhoden, Appenzell Innerrhoden, Glarus, Graubünden, Sankt Gallen, Schaffhausen, Thurgau, Zug, Zürich, and the Principality of Liechtenstein.
Research | 15 % |
(vii) What are the funding levels for the following programme areas:
Publication in peer-reviewed open access literature.
High-throughput functional characterization of protein phosphorylation sites in yeast.
Viéitez C, Busby BP, Ochoa D, Mateus A, Memon D, Galardini M, Yildiz U, Trovato M, Jawed A, Geiger AG, Oborská-Oplová M, Potel CM, Vonesch SC, Szu Tu C, Shahraz M, Stein F, Steinmetz LM, Panse VG, Noh KM, Savitski MM, Typas A, Beltrao P (2021)
Nat Biotechnol: Online ahead of print
Structural insights into the inhibition of glycine reuptake.
Shahsavar A, Stohler P, Bourenkov G, Zimmermann I, Siegrist M, Guba W, Pinard E, Sinning S, Seeger MA, Schneider TR, Dawson RJP, Nissen P (2021)
Nature 591: 677-681
Consensus management recommendations for non-tuberculous mycobacterial pulmonary diseases.
Lange C, Böttger EC, Cambau E, Griffith DE, Guglielmetti L, van Ingen J, Knight SL, Marras TK, Oliver KN, Santin M, Stout JE, Tortoli E, Wagner D, Winthrop K, Daley CL, on behalf of the expert panel group for management recommendations in NTM-PD (2021)
Lancet Infect Dis, accepted for publication
Puf6 primes 60S pre-ribosome nuclear export at low temperature.
Gerhardy S, Oborská-Oplová M, Gillet L, Börner R, van Nues R, Leitner A, Michel E, Petkowski JJ, Granneman S, Sigel RKO, Aebersold R, Panse VG (2021)
Nat Commun 12: 4696
Quorum sensing controls persistence, resuscitation, and virulence of Legionella subpopulations in biofilms.
Personnic N , Striednig B, Hilbi H (2021)
ISME J 15: 196-210
Invasive aspergillosis due to Aspergillus section Usti: a multicenter retrospective study.
Glampedakis E, Cassaing S, Fekkar A, Dannaoui E, Bougnoux ME, Bretagne S, Neofytos D, Schreiber PW, Hennequin C, Morio F, Shadrivova O, Bongomin F, Fernández-Ruiz M, Bellanger AP, Arikan-Akdagli S, Erard V, Aigner M, Paolucci M, Khanna N, Charpentier E, Bonnal C, Brun S, Gabriel F, Riat A, Zbinden R, Le Pape P, Klimko N, Lewis RE, Richardson M, İnkaya AC, Coste AT, Bochud PY, Lamoth F (2021)
Clin Infect Dis 72: 1379-1385
Quorum sensing governs a transmissive Legionella subpopulation at the pathogen vacuole periphery.
Striednig B, Lanner U, Niggli S, Katic A, Vormittag S, Brülisauer S, Hochstrasser R, Kaech A, Welin A, Flieger A, Ziegler U, Schmidt A, Hilbi H, Personnic N (2021)
EMBO Rep 22: e52972
Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis.
Becker K, Cao S, Nilsson A, Erlandsson M, Hotop SK, Kuka J, Hansen J, Haldimann K, Grinberga S, Berruga-Fernandéz T, Huseby DL, Shariatgorji R, Lindmark E, Pltazack B, Böttger EC, Crich D, Friberg LE, Vingsbo Lundberg C, Hughes D, Brönstrup M, Andrén PE, Liepinsh E, Hobbie SN (2021)
EBioMedicine 73: 103652
Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice.
Becker K, Aranzana-Climent V, Cao S, Nilsson A, Shariatgorji R, Haldimann K, Platzack B, Hughes D, Andrén P, Böttger EC, Friberg L, Hobbie SN (2021)
Clin Microbiol Infect 27: 1315-1321
Zn2+ intoxication of Mycobacterium marinum during Dictyostelium discoideum infection is counteracted by induction of the pathogen Zn2+ exporter CtpC.
Hanna N, Koliwer-Brandl H, Lefrançois LH, Kalinina V, Cardenal-Muñoz E, Appiah J, Leuba F, Gueho A, Hilbi H, Soldati T, Barisch C (2021)
mBio 12: e01313-20
The polar Legionella Icm/Dot T4SS establishes distinct contact sites with the pathogen vacuole membrane.
Böck D, Hüsler D, Steiner B, Medeiros JM, Welin A, Radomska KA, Hardt WD, Pilhofer M, Hilbi H (2021)
mBio 12: e02180-21
Model-informed drug development for antimicrobials: translational PK and PK/PD modeling to predict an efficacious human dose for apramycin.
Sou T, Hansen J, Liepinsh E, Backlund M, Ercan O, Grinberga S, Cao S, Giachou P, Petersson A, Tomczak M, Urbas M, Zabicka D, Vingsbo-Lundberg C, Hughes D, Hobbie SN, Friberg LE (2021)
Clin Pharmacol Ther 109:1063-1073
Silencing of the ER and integrative stress responses in the liver of mice with error-prone translation.
Moore J, Osinnii I, Grimm A, Oettinghaus B, Eckert A, Frank S, Böttger EC (2021)
Cells 10: 2856
Temporal and regional incidence of carbapenemase-producing Enterobacterales, Switzerland, 2013 to 2018
Ramette A, Gasser M, Nordmann P, Zbinden R, Schrenzel J, Perisa D, Kronenberg A (2021)
Euro Surveill 26: 1900760
Random errors in protein synthesis activate an age-dependent program of muscle atrophy in mice.
Moore J, Akbergenov R, Nigri M, Isnard-Petit P, Grimm A, Seebeck P, Restelli L, Frank S, Eckert A, Thiam K, Wolfer DP, Shcherbakov D, Böttger EC (2021)
Commun Biol 4: 703
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function.
Cortés Sanchón A, Santhosh Kumar H, Mantovani M, Osinnii I, Mateos JM, Kaech A, Shcherbakov D, Akbergenov R, Böttger EC (2021)
Commun Biol 4: 1350
Mitochondrial mistranslation in brain provokes a metabolic response which mitigates the age-associated decline in mitochondrial gene expression.
Shcherbakov D, Juskeviciene R, Cortés Sanchón A, Brilkova M, Rehrauer H, Laczko E, Böttger EC (2021)
Int J Mol Sci 22: 2746
Novel fidaxomicin antibiotics through site-selective catalysis.
Dailler D, Dorst A, Schäfle D, Sander P, Gademann K (2021)
Commun Chem 4: 59
Rapid Detection of PBP2a in Staphylococci from Shortly Incubated Subcultures of Positive Blood Cultures by an Immunochromatographic Assay.
Kolesnik-Goldmann N, Bodendoerfer E, Röthlin K, Herren S, Imkamp F, Marchesi M, Mancini S (2021)
Microbiol Spectr 9: e0046221
Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history.
Coscolla M, Brites D, Menardo F, Loiseau C, Borrell S, Otchere ID, Asante-Poku A, Asare P, Sanchez-Buso L, Gehre F, N'Dira Sanoussi C, Antonio M, Dissou A, Ruiz-Rodriguez P, Fyfe J, Becket P, Niemann S, Alabi AS, Grobusch MP, Kobbe R, Parkhill J, Beisel C, Fenner L, Böttger EC, Meehan CJ, Harris SR, De Jong BC, Yeboah-Manu D, Gagneux S (2021)
Microb Genom 7: 000477
Drug susceptibility distributions of Mycobacterium chimaera and other non-tuberculous mycobacteria.
Schulthess B, Schäfle D, Kälin N, Widmer T, Sander P (2021)
Antimicrob Agents Chemother 65: e02131-20
Rifabutin is inactivated by Mycobacterium abscessus Arr.
Schäfle D, Selchow P, Borer B, Meuli M, Rominski A, Schulthess B, Sander P (2021)
Antimicrob Agents Chemother 65: e02215-20
Synthesis and antibacterial activity of propylamycin derivatives functionalized at the 5"- and other positions with a view to overcoming resistance due to aminoglycoside modifying enzymes.
Lubriks D, Zogota, R, Sarpe V, Matsushita T, Sati G, Haldimann K, Gysin M, Böttger EC, Vasella A, Suna E, Hobbie SN, Crich D (2021)
ACS Infect Dis 7: 2413-2424
Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation.
Shcherbakov D, Duscha S, Juskeviciene R, Restelli LM, Frank S, Laczko E, Böttger EC (2021)
RNA 27: 265-272
Cutibacterium avidum resists surgical skin antisepsis in the groin-a potential risk factor for periprosthetic joint infection: a quality control study
Maurer SM, Kursawe L, Rahm S, Prinz J, Zinkernagel AS, Moter A, Kuster SP, Zbinden R, Zingg OP, Achermann Y (2021)
Antimicrob Resist Infect Control 10: 27
Trends of the Epidemiology of Candidemia in Switzerland: A 15-Year FUNGINOS Survey
Adam KM, Osthoff M, Lamoth F, Conen A, Erard V, Boggian K, Schreiber PW, Zimmerli S, Bochud PY, Neofytos D, Fleury M,Fankhauser H, Goldenberger D, Mühlethaler K, Riat A, Zbinden R, Kronenberg A, Quiblier C, Marchetti O, Khanna N, Fungal Infection Network of Switzerland (FUNGINOS) (2021)
Open Forum Infect Dis 8: fab471
Mycobacterium tuberculosis phosphoribosyltransferase promotes bacterial survival in macrophages by inducing histone hypermethylation in autophagy-regulated genes.
Sengupta S, Nayak B, Meuli M, Sander P, Mishra S, Sonawane A (2021)
Front Cell Infect Microbiol 11: 676456
Dictyostelium lacking the single atlastin homolog Sey1 shows aberrant ER architecture, proteolytic processes, and expansion of the Legionella-containing vacuole.
Hüsler D, Steiner B, Welin A, Striednig B, Swart AL, Molle V, Hilbi H, Letourneur F (2021)
Cell Microbiol 23: e13318
An advanced apralog with increased in-vitro and in-vivo activity toward Gram-negative pathogens and reduced ex-vivo cochleotoxicity.
Sonousi A, Quirke J, Waduge P, Janusic T, Gysin M, Haldimann K, Hobbie SN, Sha S, Schacht J, Chow Ch, Vasella A, Böttger EC, Xu S, Crich D (2021)(highlighted as "VIP Very Important Paper" by the editor)
ChemMedChem 16: 335-339
Influence of ring size in conformationally restricted ring I analogs of paromomycin on antiribosomal and antibacterial activity
Pirrone M, Hobbie SN, Vasella A, Böttger EC, Crich D (2021)
RSC Med Chem: Online ahead of print
Mycobacterium helveticum sp. nov., a novel slowly growing mycobacterial species associated with granulomatous lesions in adult swine.
Ghielmetti G, Rosato G, Trovato A, Friedel U, Kirchgaessner C, Perroulaz C, Pendl W, Figi R, Schulthess B, Bloemberg GV, Keller PM, Stephan R, Tortoli E (2021)
Int J Syst Evol Microbiol 71: 004615
Synthesis, antibacterial action and ribosome inhibition of deoxyspectinomycins.
Dharuman S, Wilt LA, Liu J, Reeve SM, Thompson CW, Elmore JM, Shcherbakov D, Lee RB, Böttger EC, Lee RE (2021)
J Antibiot 74: 381-396
Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a multicentre cohort study.
Züricher K, Reichmuth ML, Ballif M, Loiseau C, Borrell S, Reinhard M, Skrivankova V, Hömke R, Sander P, Avihingsanon A, Abimiku AG, Marcy O, Collantes J, Carter EJ, Wilkinson RJ, Cox H, Yotebieng M, Huebner R, Fenner L, Böttger EC, Gagneux S, Egger M, on behalf of IeDEA (2021)
Lancet Microbe 2: e320-330
Antimicrobial susceptibility patterns of respiratory Gram-negative bacterial isolates from COVID-19 patients in Switzerland.
Gysin M, Acevedo CT, Haldimann K, Bodendoerfer E, Imkamp F, Bulut K, Buehler PK, Brugger SD, Becker K, Hobbie SN (2021)
Ann Clin Microbiol Antimicrob 20: 64
Disseminated Mycobacterium simiae and Mycobacterium avium infection causing an immune reconstitution inflammatory syndrome in a female patient with HIV.
Bachofner JA, Ikenberg K, Schulthess B, Nemeth J (2021)
BMJ Case Rep 14: e241037
A rare case of severe gastroenteritis caused by Aeromonas hydrophila after colectomy in a patient with anti-Hu syndrome: a case report
Greiner M, Anagnostopoulos A, Pohl D, Zbinden R, Zbinden A (2021)
Case Reports BMC Infect Dis 21: 1097
Open wounds and rifampicin therapy are associated with rifampicin resistance among staphylococcal vascular graft/endograft infections(2021)
Leung YKS, Ledergerber B, Eberhard N, Mestres CA, Rancic Z, Zimmermann A, Zbinden R, Brugger SD, Zinkernagel AS, Hasse B; Vascular Graft Cohort Study (2021)
JAC Antimicrob Resist 3: dlab041
Reviews
Bacterial quorum sensing and phenotypic heterogeneity: how the collective shapes the individual.
Striednig B, Hilbi H (2021)
Trends Microbiol: Online ahead of print
Dictyostelium dynamin superfamily GTPases implicated in vesicle trafficking and host-pathogen interactions.
Katic A, Hüsler D, Letourneur F, Hilbi H (2021)
Front Cell Dev Biol: Online ahead of print
Letters
Rapid identification of CTX-M-type extended-spectrum β-lactamase-producing Enterobacterales from blood cultures using a multiplex lateral flow immunoassay
Walter A, Bodendoerfer E, Kolesnik-Goldmann N, Mancini S (2021)
J Glob Antimicrob Resist 26: 130-132
Genotypic and phenotypic analyses of aac(3) aminoglycoside-resistance gene diversity point to three distinct phenotypes of contemporary clinical relevance
Plattner M, Goyet C, Haldimann K, Gysin M, Juhas M, Becker K, Hobbie SN (2021)
J Glob Antimicrob Resist: Online ahead of print
The Institute of Medical Microbiology at the University of Zurich is the Regional Competence Center for the primary analysis of bacteriological samples suspicious of a bioterror-related background. This represents an additional and not a continuous task of the diagonstics laboratory proficient in bacteriology, mycology and serology. Research focusses on vaccine and antibiotic development, protein structure analysis, host-pathogen interaction (Legionella, Mycobacteria), antibiotic resistance mechanisms and general aspects of translation.
For further information please visit (website in french):
https://www.imm.uzh.ch/de/francais.html
(9) Including viruses and prions.