Institut für Medizinische Mikrobiologie (Institute of Medical Microbiology)

2. Где он находится (указать адрес и географическое местонахождение)?
Institut für Medizinische Mikrobiologie, Medizinische Fakultät, Universität Zürich, Gloriastrasse 30/32, CH-8006 Zürich, Switzerland

N 47° 22' 36.20", E 8° 33' 11.18"

3. Площадь лабораторных помещений с разбивкой по уровню изоляции
BL 3 , 20.00 м2
Общая площадь лабораторных помещений (м(2))

4. Организационная структура каждого объекта

(viii) Кратко охарактеризовать политику объекта в отношении публикаций

Publication in open literature.

(ix) Представить перечень общедоступных документов и докладов, явившихся результатом проделанной работы, которые были опубликованы за предыдущие 12 месяцев. (Указать авторов, названия и полные выходные данные.)

Ribosome levels selectively regulate translation and lineage commitment to human hematopoiesis. Khajuria RK, Munschauer M, Ulirsch JC, Fiorini C, Ludwig LS, McFarland SK, Abdulhay NJ, Specht H, Keshishian H, Mani DR, Jovanovic M, Ellis SR, Fulco CP, Engreitz JM, Schütz S, Lian J, Gripp KW, Weinberg OK, Pinkus GS, Gehrke L, Regev A, Lander ES, Gazda HT, Lee Wy, Panse VG, Carr SA, Sankaran VG (2018) Cell 173: 90-103.

A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study. Walker TM, Merker M, Knoblauch AM, Helbling P, Schoch OD, van der Werf MJ, Kranzer K, Fiebig L, Kröger S, Haas W, Hoffmann H, Indra A, Egli A, Cirillo DM, Robert J, Rogers TR, Groenheit R, Mengshoel AT, Mathys V, Haanperä M, Soolingen DV, Niemann S, Böttger EC, Keller PM; MDR-TB Cluster Consortium (2018) Lancet Infect Dis 18: 431-440.

Correction to: Catheter retention as a consequence rather than a cause of unfavorable outcome in candidemia. Damonti L, Erard V, Garbino J, Schrenzel J, Zimmerli S, Mühlethaler K, Imhof A, Zbinden R, Fehr J, Boggian K, Bruderer T, Flückiger U, Frei R, Orasch C, Conen A, Khanna N, Bregenzer T, Bille J, Lamoth F, Marchetti O, Bochud PY; Fungal Infection Network of Switzerland (FUNGINOS) (2018) Intensive Care Med 44: 405-407.

Atomistic Mechanism of Large-Scale Conformational Transition in a Heterodimeric ABC Exporter. Göddeke H, Timachi MH, Hutter CAJ, Galazzo L, Seeger MA, Karttunen M, Bordignon E, Schäfer LV (2018) J Am Chem Soc 140: 4543-4551.

Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2. Schütz S, Michel E, Damberger FF, Oplová M, Peña C, Leitner A, Aebersold R, Allain FH, Panse VG (2018) Nat Commun 9: 3669.

Treatment outcome definitions in nontuberculous mycobacterial pulmonary disease: an NTM-NET consensus statement. van Ingen J, Aksamit T, Andrejak C, Böttger EC, Cambau E, Daley CL, Griffith DE, Guglielmetti L, Holland SM, Huitt GA, Koh WJ, Lange C, Leitman P, Marras TK, Morimoto K, Olivier KN, Santin M, Stout JE, Thomson R, Tortoli E, Wallace RJ Jr, Winthrop KL, Wagner D; for NTM-NET (2018) Eur Respir J 51: 1800170.

Structure of a eukaryotic cytoplasmic pre-40S ribosomal subunit. Scaiola A, Peña C, Weisser M, Böhringer D, Leibundgut M, Klingauf-Nerurkar P, Gerhardy S, Panse VG, Ban N (2018) EMBO J 37: e98499.

Association of Cutibacterium avidum Colonization in the Groin With Obesity: A Potential Risk Factor for Hip Periprosthetic Joint Infection. Böni L, Kuster SP, Bartik B, Zbinden R, Zingg PO, Achermann Y (2018) Clin Infect Dis 67: 1878-1882.

Propionibacterium avidum – a virulent pathogen causing hip periprosthetic joint infection. Achermann Y, Liu J, Zbinden R, Zingg PO, Anagnostopoulos A, Barnard E, Sutter R, Li H, McDowell A, Zinkernagel AS (2018) Clin Infect Dis 66: 54-63.

Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations. Akbergenov R, Duscha S, Fritz A-K, Juskeviciene R, Oishi N, Schmitt K, Shcherbakov D, Teo Y, Boukari H, Freihofer P, Isnard-Petit P, Oettinghaus B, Frank S, Thiam K, Rehrauer H, Westhof E, Schacht J, Eckert A, Wolfer D, Böttger EC (2018) EMBO Rep 19: e46193.

The Mycobacterial LexA/RecA-Independent DNA Damage Response Is Controlled by PafBC and the Pup-Proteasome System. Müller AU, Imkamp F, Weber-Ban E (2018) Cell Reports 23: 3551-3564.

Multiplex PCR on the Bronchoalveolar Lavage Fluid of Immunocompromised Patients. Affolter K, Schumann DM, Tamm M, Jahn K, Siebeneichler A, Junker L, Wagner K, Keller PM, Frei R, Stolz D (2018) Chest 154: 722-725.

Synthetic single domain antibodies for the conformational trapping of membrane proteins. Zimmermann I, Egloff P, Hutter CA, Arnold FM, Stohler P, Bocquet N, Hug MN, Huber S, Siegrist M, Hetemann L, Gera J, Gmür S, Spies P, Gygax D, Geertsma ER, Dawson RJ, Seeger MA (2018) Elife 7: e34317.

Aortic Endograft Infection with Mycobacterium chimaera and Granulicatella adiacens, Switzerland, 2014. Plate A, Kohl TA, Keller PM, Majer S, Fulchini R, Strahm C, Medugno C, Rancic Z, Husmann L, Sax H, Niemann S, Hasse B (2018) Emerg Infect Dis 24: 1700-1704.

Global health estimate of invasive Mycobacterium chimaera infections associated with heater-cooler devices in cardiac surgery. Sommerstein R, Hasse B, Marschall J, Sax H, Genoni M, Schlegel M, Widmer AF; Swiss Chimaera Taskforce (Consiglio J, Erny S, Gardiol C, Häussler A, Keller PM, Koch D, Masserey V, Moreno R, Schulthess B, Wälti M) (2018) Emerg Infect Dis 24: 576-578.

Legionella-containing vacuoles capture PtdIns(4)P-rich vesicles derived from the Golgi apparatus. Weber S, Steiner B, Welin A, Hilbi H (2018) MBio 9: e02420-18.

Inflammatory disorders mimicking periprosthetic joint infections may result in false-positive α-defensin. Plate A, Stadler L, Sutter R, Anagnostopoulos A, Frustaci D, Zbinden R, Fucentese SF, Zinkernagel AS, Zingg PO, Achermann Y (2018) Clin Microbiol Infect 24: 1212.e1-1212.e6.

Evaluation of the Lightmix® Mycoplasma macrolide assay for the detection of macrolide resistant Mycoplasma pneumoniae in pneumonia patients. Wagner K, Imkamp F, Pires V, Keller PM (2018) Clin Microbiol Infect: Epub ahead of print.

Rapid disk diffusion antibiotic susceptibility testing for Pseudomonas aeruginosa, Acinetobacter baumanii and Enterococcus. Hombach M, Jetter M, Keller PM, Blöchliger N, Kolesnik-Goldmann N, Böttger EC (2018) J Antimicrob Chemother 73: 385-391.

Combining forecast probabilities with graphical visualization for improved reporting of antimicrobial susceptibility testing. Mancini S, Marchesi M, Blöchliger N, Schmid M, Courvalin P, Keller P, Böttger EC (2018) J Antimicrob Chemother 73: 2266-2268.

Fluconazole non-susceptible breakthrough candidemia after prolonged low-dose prophylaxis: a prospective FUNGINOS study. Orasch C, Mertz D, Garbino J, van Delden C, Emonet S, Schrenzel J, Zimmerli S, Damonti L, Mühlethaler K, Imhof A, Ruef C, Fehr J, Zbinden R, Boggian K, Bruderer T, Flückiger U, Conen A, Khanna N, Frei R, Bregenzer T, Lamoth F, Erard V, Bochud PY, Calandra T, Bille J, Marchetti O; Fungal Infection Network of Switzerland (FUNGINOS) (2018) J Infect 76: 489-495.

Effects of the 1- N-(4-amino-2 S-hydroxybutyryl) and 6'- N-(2-hydroxyethyl) substituents on ribosomal selectivity, cochleotoxicity, and antibacterial activity in the sisomicin class of aminoglycoside antibiotics. Sonousi A, Sarpe VA, Brilkova M, Schacht J, Vasella A, Böttger EC, Crich D (2018) ACS Infect Dis 4: 1114-1120.

Molecular mechanisms of intrinsic streptomycin resistance in Mycobacterium abscessus. Dal Molin M, Gut M, Rominski A, Haldimann K, Becker K, Sander P (2018) Antimicrob Agents Chemother 62: e01427-17.

A uniform cloning platform for mycobacterial genetics and protein production. Arnold FM, Hohl M, Remm S, Koliwer-Brandl H, Adenau S, Chusri S, Sander P, Hilbi H, Seeger MA (2018) Sci Rep 8: 9539.

Molecular detection of fungal pathogens in clinical specimens by 18S rDNA high-throughput screening in comparison to ITS PCR and culture. Wagner K, Springer B, Pires VP, Keller PM (2018) Sci Rep 8: 6964.

Corynebacterium species rarely cause orthopedic infections. Kalt F, Schulthess B, Sidler F, Herren S, Fucentese SF, Zingg PO, Berli M, Zinkernagel AS, Zbinden R, Achermann Y (2018) J Clin Microbiol 56: e01200-18.

Whole-Genome Sequencing of Aggregatibacter Species Isolated from Human Clinical Specimens and Description of Aggregatibacter kilianii sp. nov. Murra M, Lützen L, Barut A, Zbinden R, Lund M, Villesen P, Nørskov-Lauritsen N (2018) J Clin Microbiol 56: e00053-18.

Pathogen identification by multiplex Lightmix® RT-PCR in patients with meningitis and culture-negative cerebrospinal fluid. Wagner K, Springer B, Pires VP, Keller PM (2018) J Clin Microbiol 56: e01492-17.

A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors. Hartmann J, Münch RC, Freiling RT, Schneider IC, Dreier B, Samukange W, Koch, J, Seeger MA, Plückthun A, Buchholz CJ (2018) Mol Ther Methods Clin Dev 10: 128-143.

Quantitative imaging flow cytometry of Legionella-infected Dictyostelium reveals the impact of retrograde trafficking on pathogen vacuole composition. Welin A, Weber S, Hilbi H (2018) Appl Environ Microbiol 84: e00158-18.

Detection limit of Mycobacterium chimaera in water samples for monitoring medical device safety: insights from a pilot experimental series. Schreiber PW, Köhler N, Cervera R, Hasse B, Sax H, Keller PM (2018) J Hosp Infect 99: 284-289.

Detection of respiratory bacterial pathogens causing atypical pneumonia by multiplex Lightmix® RT-PCR. Wagner K, Springer B, Imkamp F, Opota O, Greub G, Keller PM. (2018) Int J Med Microbiol 308: 317-323.

Different Types of Heater-Cooler Units and Their Risk of Transmission of Mycobacterium chimaera During Open-Heart Surgery: Clues From Device Design. Kuehl R, Banderet F, Egli A, Keller PM, Frei R, Döbele T, Eckstein F, Widmer AF (2018) Infect Control Hosp Epidemiol 39: 834-840.

Comparison of Löwenstein-Jensen and BACTEC MGIT 960 culture for Mycobacterium tuberculosis in people living with HIV. Hongler J, Musaazi J, Ledergerber B, Eberhard N, Sekaggya-Wiltshire C, Keller PM, Fehr J, Castelnuovo B (2018) HIV Med 19: 654-661.

Influence of skin disinfection prior removal of perineural catheter on bacterial colonization, contamination and local inflammation: a prospective randomized study. Blumenthal S, Zbinden R, Mandic S, Rüst CA, Aguirre J, Borgeat A (2018) Minerva Anestesiol 84: 319-327.

A novel RT-PCR for the detection of Helicobacter pylori and identification of clarithromycin resistance mediated by mutations in the 23S rRNA gene. Redondo JR, Keller PM, Zbinden R, Wagner K. (2018) Diagn Microbiol Infect Dis 90: 1-6.

High-throughput screening of bacterial pathogens in clinical specimens using 16S rDNA qPCR and fragment analysis. Wagner K, Springer B, Pires VP, Keller PM (2018) Diagn Microbiol Infect Dis: Epub ahead of print.

Increased Pathogen Identification in Vascular Graft Infections by the Combined Use of Tissue Cultures and 16S rRNA Gene Polymerase Chain Reaction. Ajdler-Schaeffler E, Scherrer AU, Keller PM, Anagnostopoulos A, Hofmann M, Rancic Z, Zinkernagel AS, Bloemberg GV, Hasse BK; and the VASGRA Cohort (2018) Front Med (Lausanne) 5: 169.

A cluster of scedosporiosis in lung transplant candidates and recipients: The Zurich experience and review of the literature. Abela IA, Murer C, Schuurmans MM, Schmitt JW, Muller F, Imkamp F, Mueller NJ, Benden C (2018) Transpl Infect Dis 20: e12792.

Ureaplasma and Mycoplasma in kidney allograft recipients-A case series and review of the literature. Gerber L, Gaspert A, Braghetti A, Zwahlen H, Wüthrich R, Zbinden R, Mueller N, Fehr T (2018) Transpl Infect Dis 20: e12937.

Whisky, microwave or hairdryer? Exploring the most efficient way to reduce bacterial colonisation on contaminated toothbrushes. Patcas R, Zbinden R, Schätzle M, Schmidlin PR, Zehnder M (2018) Br Dent J 225: 1007-1010.

Legionella quorum sensing and its role in pathogen-host interactions. Personnic N, Striednig B, Hilbi H (2018) Curr Opin Microbiol 41: 29-35.

Membrane transporter research in times of countless structures. Seeger MA (2018) Biochim Biophys Acta 1860: 804-808.

The Role of Antibiotic-Target-Modifying and Antibiotic-Modifying Enzymes in Mycobacterium abscessus Drug Resistance. Luthra S, Rominski A, Sander P (2018) Front Microbiol 9: 2179.

Acanthamoeba and Dictyostelium as cellular models for Legionella infection. Swart AL, Harrison CF, Eichinger L, Steinert M, Hilbi H (2018) Front Cell Infect Microbiol 8: 61.

Improving the quality and workflow of bacterial genome sequencing and analysis: paving the way for a Switzerland-wide molecular epidemiological surveillance platform. Egli A, Blanc DS, Greub G, Keller PM, Lazarevic V, Lebrand A, Leib S, Neher RA, Perreten V, Ramette A, Schrenzel J, Stephan R, Wagner K, Wuethrich D, Xenarios I (2018) Swiss Med Wkly 148: w14693.

The large GTPase atlastin controls ER remodeling around a pathogen vacuole. Steiner B, Weber S, Kaech A, Ziegler U, Hilbi H (2018) Commun Integr Biol 11: 1-5.

Analysis of Legionella metabolism by pathogen vacuole proteomics. Manske C, Finsel I, Hoffmann C, Hilbi H (2018) In Meth. Mol. Biol. 1841, Microbial proteomics. Becher, D. (ed.), Springer Press; pp. 59-76.

5. Кратко охарактеризовать деятельность в области биологической защиты, осуществляемую на объекте, включая вид(ы) изучаемых микроорганизмов1 и/или токсинов, а также наружные исследования биологических аэрозолей.

The Institute of Medical Microbiology at the University of Zurich is the Regional Competence Center for the primary analysis of bacteriological samples suspicious of a bioterror-related background. This represents an additional and not a continuous task of the diagonstics laboratory proficient in bacteriology, mycology and serology.

For further information please visit (website in German):

(9) Включая вирусы и прионы.